BACKGROUND: Cutaneous melanoma is a highly invasive tumor. It enhances metastasis and resistance to immunotherapy immunosuppressive mechanisms. Understanding RNA-binding proteins (RBPs) in melanoma's immune alterations is limited. This study explore...
Sepsis-associated encephalopathy (SAE) is a major complication in intensive care units, characterized by diffuse brain dysfunction due to systemic inflammation. Despite advances in critical care medicine, SAE remains a key factor in poor patient outc...
This study aims to refine molecular subtypes via multi-omics data, develop a prognostic signature, and identify novel biomarkers in colorectal cancer (CRC). On the basis of the multi-omics data, the MOVICS R package was used to divide patients with C...
Stomach adenocarcinoma (STAD), the most prevalent histological subtype of gastric cancer, exhibits high heterogeneity and poor prognosis, posing significant therapeutic challenges. Parthanatos, a distinct form of regulated cell death mediated by poly...
Honey bees () are vital pollinators essential for maintaining ecosystem stability and global food production, but they face escalating threats from pathogens, agrochemicals, and climate change. Although proteomics has advanced our understanding of be...
Molecular medicine (Cambridge, Mass.)
Sep 25, 2025
BACKGROUND: Juvenile idiopathic arthritis (JIA) is a rare autoimmune disease arising from a complex interplay between genetic and environmental factors. Epigenetic modifications such as DNA methylation (DNAm) have been described as potential mediator...
Clinica chimica acta; international journal of clinical chemistry
Sep 19, 2025
Extracellular vesicles, particularly exosomes, are emerging as powerful tools in cancer research due to their role in intercellular communication and their capacity to reflect the molecular composition of their originating cells. Multi-omic approache...
BACKGROUND: Clear cell renal cell carcinoma represents the most prevalent histological subtype of renal malignancy Emerging evidence underscores the critical involvement of mitochondrial dysfunction in oncogenesis and tumor progression. In this study...
Data reduction and data mining are common practices for handling large-scale data from wide-ranging sources, but high-dimensional omics and imaging data sets present difficult challenges for feature extraction and data mining due to the large number ...
BACKGROUND: Ankylosing spondylitis (AS), a chronic inflammatory disorder affecting axial joints, is frequently complicated by uveitis. However, the molecular mechanisms linking AS to secondary uveitis remain poorly understood.
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.