AIMC Topic: Multiomics

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Integrated multi-omics analysis and machine learning refine molecular subtypes and clinical outcome for hepatocellular carcinoma.

Hereditas
The high morbidity and mortality of hepatocellular carcinoma (HCC) impose a substantial economic burden on patients' families and society, and the majority of HCC patients are detected at advanced stages and experience poor therapeutic outcomes, wher...

Artificial intelligence-driven integration of multi-omics and radiomics: A new hope for precision cancer diagnosis and prognosis.

Biochimica et biophysica acta. Molecular basis of disease
Despite advances in cancer diagnosis and treatment, the disease remains a major health challenge. Integrating multi-omics, radiomics, and artificial intelligence has improved detection, prognosis, and treatment monitoring. Molecular multi-omics provi...

Integrative Multi-Omics Analysis Reveals Molecular Subtypes of Ovarian Cancer and Constructs Prognostic Models.

Journal of immunotherapy (Hagerstown, Md. : 1997)
Ovarian cancer (OV) remains the most lethal gynecological malignancy. The aim of this study was to identify molecular subtypes of OV through integrative multi-omics analysis and construct machine learning-based prognostic models for predicting the ef...

MIDAA: deep archetypal analysis for interpretable multi-omic data integration based on biological principles.

Genome biology
High-throughput multi-omic molecular profiling allows the probing of biological systems at unprecedented resolution. However, integrating and interpreting high-dimensional, sparse, and noisy multimodal datasets remains challenging. Deriving new biolo...

Combining multi-omics analysis with machine learning to uncover novel molecular subtypes, prognostic markers, and insights into immunotherapy for melanoma.

BMC cancer
BACKGROUND: Melanoma (SKCM) is an extremely aggressive form of cancer, characterized by high mortality rates, frequent metastasis, and limited treatment options. Our study aims to identify key target genes and enhance the diagnostic accuracy of melan...

Integrative Multi-Omics and Routine Blood Analysis Using Deep Learning: Cost-Effective Early Prediction of Chronic Disease Risks.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Chronic noncommunicable diseases (NCDS) are often characterized by gradual onset and slow progression, but the difficulty in early prediction remains a substantial health challenge worldwide. This study aims to explore the interconnectedness of disea...

Machine learning and multi-omics integration: advancing cardiovascular translational research and clinical practice.

Journal of translational medicine
The global burden of cardiovascular diseases continues to rise, making their prevention, diagnosis and treatment increasingly critical. With advancements and breakthroughs in omics technologies such as high-throughput sequencing, multi-omics approach...

Anticancer drug response prediction integrating multi-omics pathway-based difference features and multiple deep learning techniques.

PLoS computational biology
Individualized prediction of cancer drug sensitivity is of vital importance in precision medicine. While numerous predictive methodologies for cancer drug response have been proposed, the precise prediction of an individual patient's response to drug...

Multiomics evaluation and machine learning optimize molecular classification, prediction of prognosis and immunotherapy response for ovarian cancer.

Pathology, research and practice
BACKGROUND: Ovarian cancer (OC), owing to its substantial heterogeneity and high invasiveness, has historically been devoid of precise, individualized treatment options. This study aimed to establish integrated consensus subtypes of OC using differen...

Amogel: a multi-omics classification framework using associative graph neural networks with prior knowledge for biomarker identification.

BMC bioinformatics
The advent of high-throughput sequencing technologies, such as DNA microarray and DNA sequencing, has enabled effective analysis of cancer subtypes and targeted treatment. Furthermore, numerous studies have highlighted the capability of graph neural ...