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Multiple Sclerosis

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Granger causality analysis in combination with directed network measures for classification of MS patients and healthy controls using task-related fMRI.

Computers in biology and medicine
Several studies have already assessed brain network variations in multiple sclerosis (MS) patients and healthy controls (HCs). The underlying neural system's functioning is apparently too complicated, however. Therefore, the neural time series' analy...

Analysis of defective pathways and drug repositioning in Multiple Sclerosis via machine learning approaches.

Computers in biology and medicine
BACKGROUND: Although some studies show that there could be a genetic predisposition to develop Multiple Sclerosis (MS), attempts to find genetic signatures related to MS diagnosis and development are extremely rare.

Automated Assessment of Oral Diadochokinesis in Multiple Sclerosis Using a Neural Network Approach: Effect of Different Syllable Repetition Paradigms.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Slow and irregular oral diadochokinesis represents an important manifestation of spastic and ataxic dysarthria in multiple sclerosis (MS). We aimed to develop a robust algorithm based on convolutional neural networks for the accurate detection of syl...

Exploring uncertainty measures in deep networks for Multiple sclerosis lesion detection and segmentation.

Medical image analysis
Deep learning networks have recently been shown to outperform other segmentation methods on various public, medical-image challenge datasets, particularly on metrics focused on large pathologies. For diseases such as Multiple Sclerosis (MS), however,...

Uncovering convolutional neural network decisions for diagnosing multiple sclerosis on conventional MRI using layer-wise relevance propagation.

NeuroImage. Clinical
Machine learning-based imaging diagnostics has recently reached or even surpassed the level of clinical experts in several clinical domains. However, classification decisions of a trained machine learning system are typically non-transparent, a major...

Predicting PET-derived demyelination from multimodal MRI using sketcher-refiner adversarial training for multiple sclerosis.

Medical image analysis
Multiple sclerosis (MS) is the most common demyelinating disease. In MS, demyelination occurs in the white matter of the brain and in the spinal cord. It is thus essential to measure the tissue myelin content to understand the physiopathology of MS, ...

Social Media Surveillance of Multiple Sclerosis Medications Used During Pregnancy and Breastfeeding: Content Analysis.

Journal of medical Internet research
BACKGROUND: Multiple sclerosis (MS) is a chronic neurological disease occurring mostly in women of childbearing age. Pregnant women with MS are usually excluded from clinical trials; as users of the internet, however, they are actively engaged in thr...

Disability in multiple sclerosis is associated with age and inflammatory, metabolic and oxidative/nitrosative stress biomarkers: results of multivariate and machine learning procedures.

Metabolic brain disease
The aim of this study was to evaluate the immune-inflammatory, metabolic, and nitro-oxidative stress (IM&NO) biomarkers as predictors of disability in multiple sclerosis (MS) patients. A total of 122 patients with MS were included; their disability w...

DeepHarmony: A deep learning approach to contrast harmonization across scanner changes.

Magnetic resonance imaging
Magnetic resonance imaging (MRI) is a flexible medical imaging modality that often lacks reproducibility between protocols and scanners. It has been shown that even when care is taken to standardize acquisitions, any changes in hardware, software, or...

Automatic identification of atherosclerosis subjects in a heterogeneous MR brain imaging data set.

Magnetic resonance imaging
Carotid-artery atherosclerosis (CA) contributes significantly to overall morbidity and mortality in ischemic stroke. We propose a machine learning technique to automatically identify subjects with CA from a heterogeneous cohort of magnetic resonance ...