Journal of chemical information and modeling
Sep 22, 2025
Cancer remains a major threat to human health. Tumor heterogeneity often leads to differences in tumor growth rate, invasion capacity, drug sensitivity, and prognosis, which complicates treatment strategies. Currently, drug responses are often verifi...
Clinica chimica acta; international journal of clinical chemistry
Sep 19, 2025
Extracellular vesicles, particularly exosomes, are emerging as powerful tools in cancer research due to their role in intercellular communication and their capacity to reflect the molecular composition of their originating cells. Multi-omic approache...
BACKGROUND: Tumor evolution, driven by the emergence of genetically and epigenetically distinct subclones, enables cancers to adapt to selective pressures and become more aggressive, posing a major challenge in oncology. Multi-regional sequencing has...
Recent advances in cancer research emphasize the development of physiologically relevant models to better understand tumor behavior and therapeutic responses. The tumor microenvironment (TME) plays a pivotal role in tumor progression, metastasis, and...
Deciphering the pre-malignant cell of origin (COO) of different cancers is critical for understanding tumor development and improving diagnostic and therapeutic strategies in oncology. Prior work demonstrates that somatic mutations preferentially acc...
Clinica chimica acta; international journal of clinical chemistry
Sep 15, 2025
Integrating nanotechnology and artificial intelligence (AI) revolutionizes cancer diagnostics, propelling precision medicine into a transformative era. This review examines state-of-the-art nanobiosensors capable of detecting critical biomarkers-circ...
UNLABELLED: The intratumoral microbiota has been identified as an indispensable part of the tumor microenvironment (TME). However, the relationship between the intratumoral microbiota and host gene expression, as well as its impact on prognosis and T...
Nuclear receptors (NRs) are a superfamily of ligand-activated transcription factors that regulate gene expression in response to metabolic, hormonal, and environmental signals. These receptors play a critical role in metabolic homeostasis, inflammati...
Capturing the dynamic changes in patients' internal states as they approach death due to fatal diseases remains a major challenge in understanding individual pathologies and improving end-of-life care. However, existing methods primarily focus on spe...
INTRODUCTION: There are estimated to be 3.4 million patients in the UK living after a diagnosis of cancer. We know very little about their quality of life or healthcare usage. Patient-reported outcome measures (PROMs) are tools which help to translat...
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