AIMC Topic: Nucleophosmin

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Machine learning and multi-omics integration identifies immunological predictors and mechanistic insights in autoimmune encephalitis.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] Jan 14, 2026
OBJECTIVE: To develop an interpretable prognostic prediction model for autoimmune encephalitis (AE) using immunological indicators and to investigate the potential role of nucleophosmin (NPM1) in disease pathogenesis through multi-omics approaches.
Multiomics Nuclear Proteins Middle Aged Transcriptome Nucleophosmin Encephalitis Encephalomyelitis, Autoimmune, Experimental Autoantibodies Hashimoto Disease Female Adult Animals Male Machine Learning Prognosis Humans
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DCN, NPM3 and SULF1 are hub genes related to vasculogenic mimicry in lung adenocarcinoma.

Journal of cancer research and clinical oncology Nov 8, 2025
AIM: Vasculogenic mimicry (VM), a process in which cancer cells form endothelial cell-independent vascular networks, is a hallmark of tumor aggressiveness in lung adenocarcinoma (LUAD) and supports tumor growth and metastasis. This study aims to iden...
Nucleophosmin Sulfotransferases Neovascularization, Pathologic Adenocarcinoma of Lung Mice Gene Expression Regulation, Neoplastic Nuclear Proteins Mice, Nude Gene Expression Profiling Lung Neoplasms Biomarkers, Tumor Animals Humans
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Residual disease in NPM1-mutated acute myeloid leukemia.

Clinica chimica acta; international journal of clinical chemistry Sep 3, 2025
Acute myeloid leukemia (AML) represents a genetically heterogeneous malignancy, with mutations in the nucleophosmin-1 (NPM1) gene identified as the most prevalent and clinically significant molecular biomarkers. These mutations play a crucial pivotal...
Nuclear Proteins Mutation Neoplasm, Residual Humans Leukemia, Myeloid, Acute Nucleophosmin
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Deep learning detects acute myeloid leukemia and predicts NPM1 mutation status from bone marrow smears.

Leukemia Sep 8, 2021
The evaluation of bone marrow morphology by experienced hematopathologists is essential in the diagnosis of acute myeloid leukemia (AML); however, it suffers from a lack of standardization and inter-observer variability. Deep learning (DL) can proces...
Aged Adult Biomarkers, Tumor Leukemia, Myeloid, Acute Retrospective Studies Female Humans Prognosis Follow-Up Studies Case-Control Studies Mutation Nucleophosmin Deep Learning Male Middle Aged Bone Marrow
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A novel machine-learning-derived genetic score correlates with measurable residual disease and is highly predictive of outcome in acute myeloid leukemia with mutated NPM1.

Blood cancer journal Oct 1, 2019
Adolescent Nuclear Proteins Aged, 80 and over Leukemia, Myeloid, Acute Young Adult Middle Aged Adult Survival Rate Neoplasm, Residual Humans Algorithms Mutation Genes, Neoplasm Machine Learning Aged High-Throughput Nucleotide Sequencing Nucleophosmin
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