SIGNIFICANCE: The incidence of keratinocyte carcinomas (KCs) is increasing every year, making the task of developing new methods for KC early diagnosis of utmost medical and economical importance.
Two-photon fluorescence (TPF) imaging opens a new avenue to achieve high resolution at extended penetration depths. However, it is difficult for conventional TPF imaging systems to simultaneously achieve high resolution and speed. In this work, we de...
Lifetime determination plays a crucial role in fluorescence lifetime imaging microscopy (FLIM). We introduce UNET-FLIM, a deep learning architecture based on a one-dimensional U-net, specifically designed for lifetime determination. UNET-FLIM focuses...
Medical & biological engineering & computing
Jan 22, 2025
The identification and categorization of circulating tumor cells (CTCs) in peripheral blood are imperative for advancing cancer diagnostics and prognostics. The intricacy of various CTCs subtypes, coupled with the difficulty in developing exhaustive ...
Fluorescence imaging has been widely used in fields like (pre)clinical imaging and other domains. With advancements in imaging technology and new fluorescent labels, fluorescence lifetime imaging is gradually gaining recognition. Our research departm...
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Jan 8, 2025
In clinical optical molecular imaging, the need for real-time high frame rates and low excitation doses to ensure patient safety inherently increases susceptibility to detection noise. Faced with the challenge of image degradation caused by severe no...
Photodiagnosis and photodynamic therapy
Dec 28, 2024
In recent years, interest in applying deep learning (DL) to medical diagnosis has rapidly increased, driven primarily by the development of Convolutional Neural Networks and Transformers. Despite advancements in DL, the automated diagnosis of skin ca...
Early cancer detection plays a vital role in improving the survival rate of cancer patients, underscoring the importance of developing cancer detection methods. However, it is a great challenge to achieve simple, rapid, and accurate methods for simul...
International journal of oral and maxillofacial surgery
Dec 12, 2024
The aim of this prospective study was to determine the effectiveness of screening using image processing analysis and a deep convolutional neural network (DCNN) to classify oral cancers using non-invasive fluorescence visualization. The study include...
BACKGROUND AND OBJECTIVES: Oral cancer is a global health challenge. The disease can be successfully treated if detected early, but the survival rate drops significantly for late stage cases. There is a growing interest in a shift from the current st...
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