AIMC Topic: Patient Selection

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Optimizing clinical trials recruitment via deep learning.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Clinical trials, prospective research studies on human participants carried out by a distributed team of clinical investigators, play a crucial role in the development of new treatments in health care. This is a complex and expensive proce...

Criteria2Query: a natural language interface to clinical databases for cohort definition.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Cohort definition is a bottleneck for conducting clinical research and depends on subjective decisions by domain experts. Data-driven cohort definition is appealing but requires substantial knowledge of terminologies and clinical data mode...

Machine Learning Algorithm Helps Identify Non-Diagnosed Prodromal Alzheimer's Disease Patients in the General Population.

The journal of prevention of Alzheimer's disease
BACKGROUND: Recruiting patients for clinical trials of potential therapies for Alzheimer's disease (AD) remains a major challenge, with demand for trial participants at an all-time high. The AD treatment R and D pipeline includes around 112 agents. I...

SemEHR: A general-purpose semantic search system to surface semantic data from clinical notes for tailored care, trial recruitment, and clinical research.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Unlocking the data contained within both structured and unstructured components of electronic health records (EHRs) has the potential to provide a step change in data available for secondary research use, generation of actionable medical i...

EliIE: An open-source information extraction system for clinical trial eligibility criteria.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: To develop an open-source information extraction system called Eligibility Criteria Information Extraction (EliIE) for parsing and formalizing free-text clinical research eligibility criteria (EC) following Observational Medical Outcomes P...

Automated classification of eligibility criteria in clinical trials to facilitate patient-trial matching for specific patient populations.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: To develop automated classification methods for eligibility criteria in ClinicalTrials.gov to facilitate patient-trial matching for specific populations such as persons living with HIV or pregnant women.

Machine-Learning Algorithms Predict Graft Failure After Liver Transplantation.

Transplantation
BACKGROUND: The ability to predict graft failure or primary nonfunction at liver transplant decision time assists utilization of scarce resource of donor livers, while ensuring that patients who are urgently requiring a liver transplant are prioritiz...