AIMC Topic: Peptide Library
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Supervised Learning and Mass Spectrometry Predicts the Fate of Nanomaterials.
ACS nano
Jul 3, 2019
The surface of nanoparticles changes immediately after intravenous injection because blood proteins adsorb on the surface. How this interface changes during circulation and its impact on nanoparticle distribution within the body is not understood. He...
Prosit: proteome-wide prediction of peptide tandem mass spectra by deep learning.
Nature methods
May 27, 2019
In mass-spectrometry-based proteomics, the identification and quantification of peptides and proteins heavily rely on sequence database searching or spectral library matching. The lack of accurate predictive models for fragment ion intensities impair...
Large-scale network analysis reveals the sequence space architecture of antibody repertoires.
Nature communications
Mar 21, 2019
The architecture of mouse and human antibody repertoires is defined by the sequence similarity networks of the clones that compose them. The major principles that define the architecture of antibody repertoires have remained largely unknown. Here, we...
Effective binding to protein antigens by antibodies from antibody libraries designed with enhanced protein recognition propensities.
mAbs
Jan 9, 2019
Antibodies provide immune protection by recognizing antigens of diverse chemical properties, but elucidating the amino acid sequence-function relationships underlying the specificity and affinity of antibody-antigen interactions remains challenging. ...
A novel nanobody and mimotope based immunoassay for rapid analysis of aflatoxin B1.
Talanta
Nov 6, 2018
Mimotopes could replace mycotoxins and their conjugates to develop immunoassay methods. The mimotopes obtained by phage display technology were mainly using monoclonal antibodies or polyclonal antibodies as targets. However, the mimotope of recombina...
An ultrasensitive electrochemical immunosensor for Cry1Ab based on phage displayed peptides.
Talanta
Nov 22, 2017
The rapid and widespread adoption of Bacillus thuringiensis (Bt) proteins in genetically modified (GM) crops has raised concerns about the impact of GM crops on environment and food safety. A sensitive and specific method for detecting Bt proteins in...
Protein Isoforms
Limit of Detection
Transgenes
Crops, Agricultural
Endotoxins
Gene Expression
Biosensing Techniques
Immunoassay
Biological Variation, Individual
Bacillus thuringiensis
Zea mays
Peptide Library
Electrodes
Hemolysin Proteins
Bacillus thuringiensis Toxins
Bacterial Proteins
Antibodies, Monoclonal
Electrochemical Techniques
Insecticides
Plants, Genetically Modified
Gold
Metal Nanoparticles
Phage display enables machine learning discovery of cancer antigen-specific TCRs.
Science advances
Jun 13, 2025
T cells targeting epitopes in infectious diseases or cancer play a central role in spontaneous and therapy-induced immune responses. Epitope recognition is mediated by the binding of the T cell receptor (TCR), and TCRs recognizing clinically relevant...
To Fly, or Not to Fly, That Is the Question: A Deep Learning Model for Peptide Detectability Prediction in Mass Spectrometry.
Journal of proteome research
Jun 6, 2025
Identifying detectable peptides, known as flyers, is key in mass spectrometry-based proteomics. Peptide detectability is strongly related to peptide sequences and their resulting physicochemical properties. Moreover, the high variability in MS data c...
Efficient Design of Affilin Protein Binders for HER3.
International journal of molecular sciences
May 14, 2025
Engineered scaffold-based proteins that bind to concrete targets with high affinity offer significant advantages over traditional antibodies in theranostic applications. Their development often relies on display methods, where large libraries of vari...
Deep learning-based design and experimental validation of a medicine-like human antibody library.
Briefings in bioinformatics
Nov 22, 2024
Antibody generation requires the use of one or more time-consuming methods, namely animal immunization, and in vitro display technologies. However, the recent availability of large amounts of antibody sequence and structural data in the public domain...
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