AIMC Topic: Plasmodium falciparum
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Identification of immune signatures predictive of clinical protection from malaria.
PLoS computational biology
Oct 24, 2017
Antibodies are thought to play an essential role in naturally acquired immunity to malaria. Prospective cohort studies have frequently shown how continuous exposure to the malaria parasite Plasmodium falciparum cause an accumulation of specific respo...
FABRICATION AND EVALUATION OF SMART NANOCRYSTALS OF ARTEMISININ FOR ANTIMALARIAL AND ANTIBACTERIAL EFFICACY.
African journal of traditional, complementary, and alternative medicines : AJTCAM
Nov 23, 2016
BACKGROUND: Nanocrystals have the potential to substantially increase dissolution rate, solubility with subsequent enhanced bioavailability via the oral route of a range of poor water soluble drugs. Regardless of other issues, scale up of the batch s...
Malaria Parasitemia and Parasite Density in Antiretroviral-Treated HIV-Infected Adults Following Discontinuation of Cotrimoxazole Prophylaxis.
The Journal of infectious diseases
Oct 25, 2016
BACKGROUND: Cotrimoxazole (CTX) discontinuation increases malaria incidence in human immunodeficiency virus (HIV)-infected individuals. Rates, quantity, and timing of parasitemia rebound following CTX remain undefined.
Automated Detection of P. falciparum Using Machine Learning Algorithms with Quantitative Phase Images of Unstained Cells.
PloS one
Sep 16, 2016
Malaria detection through microscopic examination of stained blood smears is a diagnostic challenge that heavily relies on the expertise of trained microscopists. This paper presents an automated analysis method for detection and staging of red blood...
Synthesis, identification and in vitro biological evaluation of some novel quinoline incorporated 1,3-thiazinan-4-one derivatives.
Bioorganic & medicinal chemistry letters
Jun 16, 2016
The present study describes the synthesis of two new series of 3-hydroxy-N-(4-oxo-2-phenyl-1,3-thiazinan-3-yl)-8-(trifluoromethyl)quinoline-2-carboxamide derivatives (4a-j) and 3-((7-chloroquinolin-4-ylamino)methyl)-2-phenyl-1,3-thiazinan-4-one deriv...
Mycobacterium tuberculosis
Gram-Negative Bacteria
Quinolines
Magnetic Resonance Spectroscopy
Clostridium tetani
Thiazines
Structure-Activity Relationship
Plasmodium falciparum
Antitubercular Agents
Antimalarials
Anti-Bacterial Agents
Microbial Sensitivity Tests
Spectroscopy, Fourier Transform Infrared
Cheminformatics Based Machine Learning Models for AMA1-RON2 Abrogators for Inhibiting Plasmodium falciparum Erythrocyte Invasion.
Molecular informatics
Jul 17, 2015
Malaria remains a dreadful disease by putting every year about 3.4 billion people at risk and resulting into mortality of 627 thousand people worldwide. Existing therapies based upon Quinines and Artemisinin-based combination therapies have started s...
Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity.
Bioorganic & medicinal chemistry
Dec 20, 2014
A large quantity of high throughput screening (HTS) data for antimalarial activity has become available in recent years. This includes both phenotypic and target-based activity. Realising the maximum value of these data remains a challenge. In this r...
Identification of therapeutics against PfPK6 protein of Plasmodium falciparum: Structure and Deep Learning approach.
Experimental parasitology
Jun 1, 2025
The Plasmodium falciparum Protein Kinase 6 (PfPK6) is a serine/threonine protein kinase categorized under the CMGC group, displaying both cyclin-dependent kinases (CDKs) and mitogen-activated protein kinases (MAPKs) activity. Previous research has in...
Increasing a microscope's effective field of view via overlapped imaging and machine learning.
Optics express
Jan 17, 2022
This work demonstrates a multi-lens microscopic imaging system that overlaps multiple independent fields of view on a single sensor for high-efficiency automated specimen analysis. Automatic detection, classification and counting of various morpholog...
Antiplasmodial activity of some phenolic compounds from Cameroonians Allanblackia.
African health sciences
Sep 1, 2015
BACKGROUND: Plasmodium falciparum, one of the causative agents of malaria, has high adaptability through mutation and is resistant to many types of anti-malarial drugs. This study presents an in vitro assessment of the antiplasmodial activity of some...
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