AIMC Topic: Prospective Studies

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Cost-effectiveness of a novel AI technology to quantify coronary inflammation and cardiovascular risk in patients undergoing routine coronary computed tomography angiography.

European heart journal. Quality of care & clinical outcomes
AIMS: Coronary computed tomography angiography (CCTA) is a first-line investigation for chest pain in patients with suspected obstructive coronary artery disease (CAD). However, many acute cardiac events occur in the absence of obstructive CAD. We as...

Fetal growth disorders detection during first trimester gestation through comprehensive maternal circulating DNA profiling.

Human molecular genetics
BACKGROUND: Early diagnosis, close follow-up and timely delivery constitute the main elements for appropriate detection and management of Fetal Growth Disorders (FGD). We hypothesized that fetoplacental FGD-associated alterations can be detected in c...

Clinical correlations of plasma sphingosine-1-phosphate and sphingolipid key enzymes in severe dengue using laboratory and machine learning approach.

Clinica chimica acta; international journal of clinical chemistry
BACKGROUND: Sphingolipids are crucial for vascular integrity and cellular homeostasis, with recent studies highlighting their role in viral diseases.

Novel Transcriptomic Signatures in Fibrostenotic Crohn's Disease: Dysregulated Pathways, Promising Biomarkers, and Putative Therapeutic Targets.

Inflammatory bowel diseases
BACKGROUND: Fibrosis is a common complication in Crohn's disease (CD), often leading to intestinal strictures. This study aims to explore the transcriptomic signature of fibrostenotic ileal CD for a comprehensive characterization of biological and ce...

Development of a Diagnostic Prediction Model for Post-Stroke Cognitive Impairment in Acute Large Vessel Occlusion Stroke Using Multimodal MRI and PET/CT: A Study Protocol.

Brain and behavior
OBJECTIVE: Stroke is a leading cause of morbidity and disability worldwide. Post-stroke cognitive impairment (PSCI) significantly affects long-term prognosis in acute anterior circulation large-vessel occlusion stroke (LVO-AIS). This study aims to de...

A Machine Learning Algorithm to Estimate the Probability of a True Scaphoid Fracture After Wrist Trauma.

The Journal of hand surgery
PURPOSE: To identify predictors of a true scaphoid fracture among patients with radial wrist pain following acute trauma, train 5 machine learning (ML) algorithms in predicting scaphoid fracture probability, and design a decision rule to initiate adv...

Machine Learning Insights Into Amputation Risk: Evaluating Wound Classification Systems in Diabetic Foot Ulcers.

International wound journal
This study compares the performance of various wound classification systems to determine which system most effectively predicts amputation risk in diabetic foot ulcer (DFU) patients. Additionally, it identifies the key clinical and socioeconomic fact...

Predicting long-term patency of radiocephalic arteriovenous fistulas with machine learning and the PREDICT-AVF web app.

Scientific reports
The goal of this study was to expand our previously created prediction tool (PREDICT-AVF) and web app by estimating long-term primary and secondary patency of radiocephalic AVFs. The data source was 911 patients from PATENCY-1 and PATENCY-2 randomize...

A simulated annealing-based Bayesian network structure optimization framework for late morbidity prediction with a large prospective dataset.

Medical physics
BACKGROUND: Bayesian networks are seeing increased usage in healthcare, particularly for modeling complex treatment decisions under uncertainty. Bayesian networks offer significant advantages over classical machine learning and deep learning techniqu...

Evaluating large language and large reasoning models as decision support tools in emergency internal medicine.

Computers in biology and medicine
BACKGROUND: Large Language Models (LLMs) hold promise for clinical decision support, but their real-world performance varies. We compared three leading models (OpenAI's "o1" Large Reasoning Model (LRM), Anthropic's Claude-3.5-Sonnet, and Meta's Llama...