PURPOSE: To develop a fully AI-based dose estimation model capable of learning and estimating single pencil beam dose distributions, and to verify its performance by testing the model's generalizability on unseen, previously delivered treatment plans...
BACKGROUND: Proton pencil beam scanning (PBS) treatment planning for head and neck (H&N) cancers is a time-consuming and experience-demanding task where a large number of potentially conflicting planning objectives are involved. Deep reinforcement le...
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Jan 9, 2025
BACKGROUND AND PURPOSE: Few studies have examined the factors associated with xerostomia during proton and carbon ion radiotherapy for head and neck cancer (HNC), which are reported to have fewer toxic effects compared to traditional photon-based rad...
Image-guided treatment adaptation is a game changer in oncological particle therapy (PT), especially for younger patients. The purpose of this study is to present a cycle generative adversarial network (CycleGAN)-based method for synthetic computed t...
. Intensity modulated proton therapy (IMPT) is susceptible to uncertainties in patient setup and proton range. Robust optimization is employed in IMPT treatment planning to ensure sufficient coverage of the clinical target volume (CTV) in predefined ...
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
Nov 1, 2024
PURPOSE: Comprehensive Quality Assurance (QA) protocols are necessary for complex beam delivery systems like Pencil Beam Scanning (PBS) proton therapy. This study focuses on automating the evaluation of beam delivery accuracy using irradiation log fi...
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
Sep 21, 2024
PURPOSE: X-ray and proton irradiation have been reported to induce distinct modifications in cytokine expression in vitro and in vivo, suggesting a dissimilar inflammatory response between X-rays and protons. We aimed to investigate the differences i...
. Previous methods for robustness evaluation rely on dose calculation for a number of uncertainty scenarios, which either fails to provide statistical meaning when the number is too small (e.g., ∼8) or becomes unfeasible in daily clinical practice wh...
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