AIMC Topic: Proton Therapy

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Deep learning prediction of scenario doses for direct plan robustness evaluations in IMPT for head-and-neck.

Physics in medicine and biology
. Intensity modulated proton therapy (IMPT) is susceptible to uncertainties in patient setup and proton range. Robust optimization is employed in IMPT treatment planning to ensure sufficient coverage of the clinical target volume (CTV) in predefined ...

Assessment of pencil beam scanning proton therapy beam delivery accuracy through machine learning and log file analysis.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
PURPOSE: Comprehensive Quality Assurance (QA) protocols are necessary for complex beam delivery systems like Pencil Beam Scanning (PBS) proton therapy. This study focuses on automating the evaluation of beam delivery accuracy using irradiation log fi...

Differential plasma cytokine variation following X-ray or proton brain irradiation using machine-learning approaches.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
PURPOSE: X-ray and proton irradiation have been reported to induce distinct modifications in cytokine expression in vitro and in vivo, suggesting a dissimilar inflammatory response between X-rays and protons. We aimed to investigate the differences i...

Online Adaptive Proton Therapy Facilitated by Artificial Intelligence-Based Autosegmentation in Pencil Beam Scanning Proton Therapy.

International journal of radiation oncology, biology, physics
PURPOSE: Online adaptive proton therapy (oAPT) is essential to address interfractional anatomical changes in patients receiving pencil beam scanning proton therapy. Artificial intelligence (AI)-based autosegmentation can increase the efficiency and a...

Deep learning-based statistical robustness evaluation of intensity-modulated proton therapy for head and neck cancer.

Physics in medicine and biology
. Previous methods for robustness evaluation rely on dose calculation for a number of uncertainty scenarios, which either fails to provide statistical meaning when the number is too small (e.g., ∼8) or becomes unfeasible in daily clinical practice wh...

Clinical implementation of deep learning robust IMPT planning in oropharyngeal cancer patients: A blinded clinical study.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
BACKGROUND AND PURPOSE: This study aimed to evaluate the plan quality of our deep learning-based automated treatment planning method for robustly optimized intensity-modulated proton therapy (IMPT) plans in patients with oropharyngeal carcinoma (OPC)...

The emerging role of Artificial Intelligence in proton therapy: A review.

Critical reviews in oncology/hematology
Artificial intelligence (AI) has made a tremendous impact in the space of healthcare, and proton therapy is not an exception. Proton therapy has witnessed growing popularity in oncology over recent decades, and researchers are increasingly looking to...

A deep-learning-based surrogate model for Monte-Carlo simulations of the linear energy transfer in primary brain tumor patients treated with proton-beam radiotherapy.

Physics in medicine and biology
This study explores the use of neural networks (NNs) as surrogate models for Monte-Carlo (MC) simulations in predicting the dose-averaged linear energy transfer (LET) of protons in proton-beam therapy based on the planned dose distribution and patien...

Proton spot dose estimation based on positron activity distributions with neural network.

Medical physics
BACKGROUND: Positron emission tomography (PET) has been investigated for its ability to reconstruct proton-induced positron activity distributions in proton therapy. This technique holds potential for range verification in clinical practice. Recently...

Patient-specific deep learning for 3D protoacoustic image reconstruction and dose verification in proton therapy.

Medical physics
BACKGROUND: Protoacoustic (PA) imaging has the potential to provide real-time 3D dose verification of proton therapy. However, PA images are susceptible to severe distortion due to limited angle acquisition. Our previous studies showed the potential ...