AIMC Topic: RNA, Messenger
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Deep Learning-Based Medical Data Association Rules to Explore the Connectivity and Regulation Mechanism of miRNA-mRNA Network in Myocarditis.
Computational and mathematical methods in medicine
Sep 23, 2022
Acute, chronic myocarditis as myocardial localized or diffuse inflammation lesions is usually involving cardiac function in patients with severe adverse outcomes such as heart failure, sudden death, and no unified, but its pathogenesis clinical is ma...
DLm6Am: A Deep-Learning-Based Tool for Identifying N6,2'-O-Dimethyladenosine Sites in RNA Sequences.
International journal of molecular sciences
Sep 20, 2022
N6,2'-O-dimethyladenosine (mAm) is a post-transcriptional modification that may be associated with regulatory roles in the control of cellular functions. Therefore, it is crucial to accurately identify transcriptome-wide mAm sites to understand under...
Exposure to nitrate induces alterations in blood parameter responses, liver immunity, and lipid metabolism in juvenile turbot (Scophthalmus maximus).
Aquatic toxicology (Amsterdam, Netherlands)
Aug 24, 2022
Nitrate (NO) pollution of waterbodies has attracted significant global attention as it poses a serious threat to aquatic organisms and human beings. This study aimed to evaluate the role of NO, an end product of biological nitrification processes, in...
Humans
Tumor Necrosis Factor-alpha
Animals
Lipid Metabolism
Muramidase
Peroxisome Proliferator-Activated Receptors
Immunoglobulin M
Heat-Shock Proteins
Carnitine O-Palmitoyltransferase
Flatfishes
Complement C3
Nitrates
Sterol Regulatory Element Binding Protein 1
Complement C4
Fish Proteins
Liver X Receptors
RNA, Messenger
Alanine Transaminase
Water Pollutants, Chemical
Aspartate Aminotransferases
Liver
A miRNA Target Prediction Model Based on Distributed Representation Learning and Deep Learning.
Computational and mathematical methods in medicine
Jul 25, 2022
MicroRNAs (miRNAs) are a kind of noncoding RNA, which plays an essential role in gene regulation by binding to messenger RNAs (mRNAs). Accurate and rapid identification of miRNA target genes is helpful to reveal the mechanism of transcriptome regulat...
Effect of clove on improving running ability in aging mice.
Journal of food biochemistry
Jul 19, 2022
In this study, a D-galactose-induced aging mouse model was established, and Syringa oblata Lindl. extract (SOLE) was administered orally to observe the effect and mechanism of SOLE on the running ability of aging mice. The role of SOLE was evaluated ...
A deep learning method for miRNA/isomiR target detection.
Scientific reports
Jun 23, 2022
Accurate identification of microRNA (miRNA) targets at base-pair resolution has been an open problem for over a decade. The recent discovery of miRNA isoforms (isomiRs) adds more complexity to this problem. Despite the existence of many methods, none...
Identification of Functional piRNAs Using a Convolutional Neural Network.
IEEE/ACM transactions on computational biology and bioinformatics
Jun 3, 2022
Piwi-interacting RNAs (piRNAs) are a distinct sub-class of small non-coding RNAs that are mainly responsible for germline stem cell maintenance, gene stability, and maintaining genome integrity by repression of transposable elements. piRNAs are also ...
ScoMorphoFISH: A deep learning enabled toolbox for single-cell single-mRNA quantification and correlative (ultra-)morphometry.
Journal of cellular and molecular medicine
May 20, 2022
Increasing the information depth of single kidney biopsies can improve diagnostic precision, personalized medicine and accelerate basic kidney research. Until now, information on mRNA abundance and morphologic analysis has been obtained from differen...
DeepTESR: A Deep Learning Framework to Predict the Degree of Translational Elongation Short Ramp for Gene Expression Control.
ACS synthetic biology
May 3, 2022
Controlling translational elongation is essential for efficient protein synthesis. Ribosome profiling has revealed that the speed of ribosome movement is correlated with translational efficiency in the translational elongation ramp. In this work, we ...
Inferring protein expression changes from mRNA in Alzheimer's dementia using deep neural networks.
Nature communications
Feb 3, 2022
Identifying the molecular systems and proteins that modify the progression of Alzheimer's disease and related dementias (ADRD) is central to drug target selection. However, discordance between mRNA and protein abundance, and the scarcity of proteomic...
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