AIMC Topic: Scleroderma, Systemic
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Computed tomography-derived quantitative imaging biomarkers enable the prediction of disease manifestations and survival in patients with systemic sclerosis.
RMD open
Jun 25, 2025
INTRODUCTION: Systemic sclerosis (SSc) is a complex inflammatory vasculopathy with diverse symptoms and variable disease progression. Despite its known impact on body composition (BC), clinical decision-making has yet to incorporate these biomarkers....
Neural network analysis as a novel skin outcome in a trial of belumosudil in patients with systemic sclerosis.
Arthritis research & therapy
Apr 11, 2025
BACKGROUND: The modified Rodnan skin score (mRSS), a measure of systemic sclerosis (SSc) skin thickness, is agnostic to inflammation and vasculopathy. Previously, we demonstrated the potential of neural network-based digital pathology applied to SSc ...
Unique and shared transcriptomic signatures underlying localized scleroderma pathogenesis identified using interpretable machine learning.
JCI insight
Apr 8, 2025
Using transcriptomic profiling at single-cell resolution, we investigated cell-intrinsic and cell-extrinsic signatures associated with pathogenesis and inflammation-driven fibrosis in both adult and pediatric patients with localized scleroderma (LS)....
Automated AI-based image analysis for quantification and prediction of interstitial lung disease in systemic sclerosis patients.
Respiratory research
Jan 24, 2025
BACKGROUND: Systemic sclerosis (SSc) is a rare connective tissue disease associated with rapidly evolving interstitial lung disease (ILD), driving its mortality. Specific imaging-based biomarkers associated with the evolution of lung disease are need...
Common biomarkers of idiopathic pulmonary fibrosis and systemic sclerosis based on WGCNA and machine learning.
Scientific reports
Jan 3, 2025
Interstitial lung disease (ILD) is known to be a major complication of systemic sclerosis (SSc) and a leading cause of death in SSc patients. As the most common type of ILD, the pathogenesis of idiopathic pulmonary fibrosis (IPF) has not been fully e...
Quantification of coronary artery calcification in systemic sclerosis using visual ordinal and deep learning scoring: Association with systemic sclerosis clinical features.
Seminars in arthritis and rheumatism
Nov 20, 2024
OBJECTIVE: To investigate the association between systemic sclerosis (SSc) clinical features and the extent and progression of coronary artery calcifications.
Deep Learning to Detect Pulmonary Hypertension from the Chest X-Ray Images of Patients with Systemic Sclerosis.
International heart journal
Nov 14, 2024
Pulmonary hypertension (PH) is a serious prognostic complication in patients with systemic sclerosis (SSc). Deep learning models can be applied to detect PH in the chest X-ray images of these patients. The aim of the study was to investigate the perf...
Explainable fully automated CT scoring of interstitial lung disease for patients suspected of systemic sclerosis by cascaded regression neural networks and its comparison with experts.
Scientific reports
Nov 4, 2024
Visual scoring of interstitial lung disease in systemic sclerosis (SSc-ILD) from CT scans is laborious, subjective and time-consuming. This study aims to develop a deep learning framework to automate SSc-ILD scoring. The automated framework is a casc...
Analysis of nailfold capillaroscopy images with artificial intelligence: Data from literature and performance of machine learning and deep learning from images acquired in the SCLEROCAP study.
Microvascular research
Oct 9, 2024
OBJECTIVE: To evaluate the performance of machine learning and then deep learning to detect a systemic scleroderma (SSc) landscape from the same set of nailfold capillaroscopy (NC) images from the French prospective multicenter observational study SC...
Use of artificial intelligence algorithms to analyse systemic sclerosis-interstitial lung disease imaging features.
Rheumatology international
Aug 29, 2024
The use of artificial intelligence (AI) in high-resolution computed tomography (HRCT) for diagnosing systemic sclerosis-associated interstitial lung disease (SSc-ILD) is relatively limited. This study aimed to analyse lung HRCT images of patients wit...
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