AIMC Topic: Sensitivity and Specificity

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Development and validation of a LC-MS/MS assay for quantification of cisplatin in rat plasma and urine.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Till date, no analytical method published to detect Cisplatin has been validated according to the U.S. Food and Drug Administration (FDA) guidance using liquid chromatography mass spectrometry (LC-MS/MS). We report, a validated LC-MS/MS method for qu...

A Natural Language Processing-based Model to Automate MRI Brain Protocol Selection and Prioritization.

Academic radiology
RATIONALE AND OBJECTIVES: Incorrect imaging protocol selection can contribute to increased healthcare cost and waste. To help healthcare providers improve the quality and safety of medical imaging services, we developed and evaluated three natural la...

Quantifying Risk for Anxiety Disorders in Preschool Children: A Machine Learning Approach.

PloS one
Early childhood anxiety disorders are common, impairing, and predictive of anxiety and mood disorders later in childhood. Epidemiological studies over the last decade find that the prevalence of impairing anxiety disorders in preschool children range...

Enhancing analysis throughput, sensitivity and specificity in LC/ESI-MS/MS assay of plasma 25-hydroxyvitamin D by derivatization with triplex 4-(4-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) isotopologues.

Journal of pharmaceutical and biomedical analysis
The plasma/serum concentration of 25-hydroxyvitamin D [25(OH)D] is a diagnostic index for vitamin D deficiency/insufficiency, which is associated with a wide range of diseases, such as rickets, cancer and diabetes. We have reported that the derivatiz...

Noninvasive Personalization of a Cardiac Electrophysiology Model From Body Surface Potential Mapping.

IEEE transactions on bio-medical engineering
GOAL: We use noninvasive data (body surface potential mapping, BSPM) to personalize the main parameters of a cardiac electrophysiological (EP) model for predicting the response to different pacing conditions.

Segmentation of Fetal Left Ventricle in Echocardiographic Sequences Based on Dynamic Convolutional Neural Networks.

IEEE transactions on bio-medical engineering
Segmentation of fetal left ventricle (LV) in echocardiographic sequences is important for further quantitative analysis of fetal cardiac function. However, image gross inhomogeneities and fetal random movements make the segmentation a challenging pro...

Lung nodule classification using deep feature fusion in chest radiography.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Lung nodules are small, round, or oval-shaped masses of tissue in the lung region. Early diagnosis and treatment of lung nodules can significantly improve the quality of patients' lives. Because of their small size and the interlaced nature of chest ...

The Variability of Translocator Protein Signal in Brain and Blood of Genotyped Healthy Humans Using In Vivo I-CLINDE SPECT Imaging: A Test-Retest Study.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
I-CLINDE is a radiotracer developed for SPECT and targets the 18-kDa translocator protein (TSPO). TSPO is upregulated in glial cells and used as a measure of neuroinflammation in a variety of central nervous system diseases. The aim of this study was...

Quantitative EEG Evaluation During Robot-Assisted Foot Movement.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Passiveand imagined limbmovements induce changes in cerebral oscillatory activity. Central modulatory effects play a role in plastic changes, and are of uttermost importance in rehabilitation. This has extensively been studied for upper limb, but les...

Development of a plasminogen activator inhibitor (PAI-1) assay and comparison of plasma PAI-1 activity in hyperlipidemic/dyslipidemic dogs with either hyperadrenocorticism or diabetes mellitus, and healthy dogs.

Research in veterinary science
Thrombosis is a serious complication of many canine diseases and may be related to decreased fibrinolytic potential. Plasminogen activator inhibitor-1 (PAI-1) is the key regulator of fibrinolysis with increased levels demonstrated in states of pro-th...