Sepsis is a condition resulting from the uncontrolled immune response to infection, leading to widespread inflammatory damage and potentially fatal organ dysfunction. Currently, there is a lack of specific prevention and treatment strategies for seps...
Sepsis remains a leading cause of mortality worldwide, driven by its clinical complexity and delayed recognition. Artificial intelligence (AI) offers promising solutions to improve sepsis care through earlier detection, risk stratification, and perso...
Sepsis is a systemic inflammatory response syndrome caused by infection, which has a high morbidity and mortality. Short-chain fatty acids (SCFAs) have been proved to improve the outcome of sepsis by regulating immunity and metabolism, but its specif...
BACKGROUND: Sepsis is frequently combined with acute liver failure (ALF), a critical determinant in the mortality of septic patients. Pyroptosis is a significant form of programmed cell death that plays an important role in the inflammatory response....
Patients with cirrhosis face an elevated risk of developing sepsis, leading to an escalating mortality rate. This study focuses on the link between natural killer (NK) cells, cirrhosis, and sepsis. Our goal is to identify NK cell-related genes that c...
BACKGROUND: Sepsis after hip fracture in elderly people is a risk factor for mortality. The purpose of this study was to screen for risk factors for 60-day sepsis morbidity after hip fracture and to establish a predictive model using various machine ...
Sepsis, marked by hyperinflammation and subsequent immunosuppression, lacks effective phase-specific therapies. Although anisodamine hydrobromide (Ani HBr) reduced 28-day mortality in our prior trial, its mechanisms remained unclear. Here, we integra...
The existing literature lacks a comprehensive analysis of the clinical evolution of septic patients, which is highly heterogeneous and patient-dependent. The aim of this study is to develop machine learning models capable of predicting the clinical e...
Disturbed calcium homeostasis in patients with sepsis is associated with poor prognosis; however, its dynamic pattern and clinical significance remain unclear. This study aimed to establish an early warning system for calcium homeostasis in sepsis by...
BMC medical informatics and decision making
Jul 21, 2025
BACKGROUND: Nosocomial infections are a major cause of morbidity and mortality in the ICU. Earlier identification of these complications may facilitate better clinical management and improve outcomes. We developed a dynamic prediction model that leve...
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