AIMC Topic: Sepsis
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Exploring the molecular mechanisms of lactylation-related biological functions and immune regulation in sepsis-associated acute kidney injury.
Clinical and experimental medicine
Jun 12, 2025
Lactylation, a novel post-translational modification, has been implicated in various pathophysiological processes; however, its role in sepsis-associated acute kidney injury (SA-AKI) remains unclear. This study aimed to investigate the expression pat...
Machine learning models for predicting severe acute kidney injury in patients with sepsis-induced myocardial injury.
Scientific reports
Jun 4, 2025
Severe acute kidney injury (sAKI) is a prevalent and serious complication among patients with sepsis-induced myocardial injury (SIMI). Prompt and early prediction of sAKI has an important role in timely intervention, ultimately improving the patients...
A machine learning-based prediction model for sepsis-associated delirium in intensive care unit patients with sepsis-associated acute kidney injury.
Renal failure
Jun 2, 2025
Sepsis-associated acute kidney injury (SA-AKI) patients in the ICU often suffer from sepsis-associated delirium (SAD), which is linked to unfavorable outcomes. This research aimed to develop a machine learning-based model for early SAD prediction in ...
Discovery of CYP1A1 Inhibitors for Host-Directed Therapy against Sepsis.
Journal of medicinal chemistry
May 29, 2025
Bacterial sepsis remains a leading cause of death globally, exacerbated by the rise of multidrug resistance (MDR). Host-directed therapy (HDT) has emerged as a promising nonantibiotic approach to combat infections; thus, multiple HDT targets have bee...
Immunogenic cell death biomarkers for sepsis diagnosis and mechanism via integrated bioinformatics.
Scientific reports
May 27, 2025
Immunogenic cell death (ICD) has been implicated in sepsis, a condition with high mortality, through mechanisms involving endoplasmic reticulum stress and other pathophysiological pathways. This study aimed to identify and validate ICD-related biomar...
Analysis of the heterogeneous treatment effect of vasoactive drug dosage and time on hospital mortality across different sepsis phenotypes: a retrospective cohort study.
European journal of medical research
May 24, 2025
BACKGROUND: The heterogeneity of sepsis poses challenges for the individualized treatment of vasoactive drugs.
Machine learning-based text mining for cutaneous myiasis and potential value of an accidental maggot therapy for complicated skin and soft tissue infection with sepsis.
Frontiers in cellular and infection microbiology
May 6, 2025
BACKGROUND: Cutaneous myiasis, one of the most frequently diagnosed myiasis types, is defined as skin or soft tissue on a living host infested by dipterous larvae (maggots). However, bibliometric analysis of this disease remains sparse. Machine learn...
Identification of pyroptosis-related gene S100A12 as a potential diagnostic biomarker for sepsis through bioinformatics analysis and machine learning.
Molecular immunology
May 2, 2025
Sepsis is a non-discriminatory inflammatory reaction that can result in a diverse array of organ dysfunctions, which can be fatal. Pyroptosis is a programmed mechanism of cell death that is distinguishable from apoptosis and other forms of cellular d...
ADT²R: Adaptive Decision Transformer for Dynamic Treatment Regimes in Sepsis.
IEEE transactions on neural networks and learning systems
May 2, 2025
Dynamic treatment regimes (DTRs), which comprise a series of decisions taken to select adequate treatments, have attracted considerable attention in the clinical domain, especially from sepsis researchers. Existing sepsis DTR learning studies are mai...
Explainable Machine Learning Model for Predicting Persistent Sepsis-Associated Acute Kidney Injury: Development and Validation Study.
Journal of medical Internet research
Apr 28, 2025
BACKGROUND: Persistent sepsis-associated acute kidney injury (SA-AKI) shows poor clinical outcomes and remains a therapeutic challenge for clinicians. Early identification and prediction of persistent SA-AKI are crucial.
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