AIMC Topic:
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Identification of prokaryotic promoters and their strength by integrating heterogeneous features.

Genomics Aug 19, 2019
The promoter is a regulatory DNA region and important for gene transcriptional regulation. It is located near the transcription start site (TSS) upstream of the corresponding gene. In the post-genomics era, the availability of data makes it possible ...
Software Deep Learning Sequence Analysis, DNA Promoter Regions, Genetic Genome, Bacterial Genome, Archaeal
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Predicting the acute ecotoxicity of chemical substances by machine learning using graph theory.

Chemosphere Aug 16, 2019
Accurate in silico predictions of chemical substance ecotoxicity has become an important issue in recent years. Most conventional methods, such as the Ecological Structure-Activity Relationship (ECOSAR) model, cluster chemical substances empirically ...
Quantitative Structure-Activity Relationship Water Pollution, Chemical Ecotoxicology Fishes Daphnia Linear Models Machine Learning Risk Assessment Software Models, Theoretical Water Pollutants, Chemical Computer Simulation Animals
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Closed-loop cycles of experiment design, execution, and learning accelerate systems biology model development in yeast.

Proceedings of the National Academy of Sciences of the United States of America Aug 16, 2019
One of the most challenging tasks in modern science is the development of systems biology models: Existing models are often very complex but generally have low predictive performance. The construction of high-fidelity models will require hundreds/tho...
Software Computational Biology Systems Biology Robotics Saccharomyces cerevisiae Gene Expression Regulation, Fungal
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An interpretable natural language processing system for written medical examination assessment.

Journal of biomedical informatics Aug 14, 2019
OBJECTIVE: The assessment of written medical examinations is a tedious and expensive process, requiring significant amounts of time from medical experts. Our objective was to develop a natural language processing (NLP) system that can expedite the as...
Data Curation Licensure, Medical Schools, Medical Pattern Recognition, Automated Unified Medical Language System Medical Records Reproducibility of Results Clinical Competence Educational Measurement Data Collection Education, Medical Humans Software Fuzzy Logic Algorithms Natural Language Processing
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A Heuristic Approach to Overcome Architectural Barriers Using a Robotic Wheelchair.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society Aug 9, 2019
The Mobility Enhancement roBotic (MEBot) wheelchair was developed to improve the safety and accessibility of wheelchair users when facing architectural barriers. MEBot uses pneumatic actuators attached to its frame and six wheels to provide curb asce...
Female Aged Adult Humans Software Algorithms Robotics Equipment Design Heuristics Wheelchairs Male Middle Aged Architectural Accessibility
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Architecture and usability of OntoKeeper, an ontology evaluation tool.

BMC medical informatics and decision making Aug 8, 2019
BACKGROUND: The existing community-wide bodies of biomedical ontologies are known to contain quality and content problems. Past research has revealed various errors related to their semantics and logical structure. Automated tools may help to ease th...
Biological Ontologies Humans Knowledge Software Semantics
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PaleAle 5.0: prediction of protein relative solvent accessibility by deep learning.

Amino acids Aug 6, 2019
Predicting the three-dimensional structure of proteins is a long-standing challenge of computational biology, as the structure (or lack of a rigid structure) is well known to determine a protein's function. Predicting relative solvent accessibility (...
Protein Structure, Secondary Evolution, Chemical Algorithms Deep Learning Computational Biology Software Solvents Proteins Entropy Amino Acids
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Performance of machine learning software to classify breast lesions using BI-RADS radiomic features on ultrasound images.

European radiology experimental Aug 5, 2019
BACKGROUND: The purpose of this work was to evaluate computable Breast Imaging Reporting and Data System (BI-RADS) radiomic features to classify breast masses on ultrasound B-mode images.
Machine Learning Software Algorithms Humans Breast Neoplasms Middle Aged Prospective Studies Ultrasonography, Mammary Female Breast Diseases Adult
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A neural network-based software to recognise blepharospasm symptoms and to measure eye closure time.

Computers in biology and medicine Jul 31, 2019
Blepharospasm (BSP) is an adult-onset focal dystonia with phenomenologically heterogeneous effects, including, but not limited to, blinks, brief or prolonged spasms, and a narrowing or closure of the eyelids. In spite of the clear and well-known symp...
Female Middle Aged Blepharospasm Humans Aged Severity of Illness Index Neural Networks, Computer Blinking Male Diagnosis, Computer-Assisted Software
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Sequence assignment for low-resolution modelling of protein crystal structures.

Acta crystallographica. Section D, Structural biology Jul 31, 2019
The performance of automated model building in crystal structure determination usually decreases with the resolution of the experimental data, and may result in fragmented models and incorrect side-chain assignment. Presented here are new methods for...
Proteins Databases, Protein Datasets as Topic Amino Acid Sequence Machine Learning Software Crystallography, X-Ray Algorithms Protein Conformation Molecular Docking Simulation
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