AIMC Topic:
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AxonDeepSeg: automatic axon and myelin segmentation from microscopy data using convolutional neural networks.

Scientific reports Feb 28, 2018
Segmentation of axon and myelin from microscopy images of the nervous system provides useful quantitative information about the tissue microstructure, such as axon density and myelin thickness. This could be used for instance to document cell morphom...
Myelin Sheath Axons Automation Neural Networks, Computer Image Processing, Computer-Assisted Software Mice Animals Microscopy
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Gene function prediction based on Gene Ontology Hierarchy Preserving Hashing.

Genomics Feb 23, 2018
Gene Ontology (GO) uses structured vocabularies (or terms) to describe the molecular functions, biological roles, and cellular locations of gene products in a hierarchical ontology. GO annotations associate genes with GO terms and indicate the given ...
Software Animals Mice Rats Semantics Gene Ontology Humans
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Knowledge-Based Conformer Generation Using the Cambridge Structural Database.

Journal of chemical information and modeling Feb 22, 2018
Fast generation of plausible molecular conformations is central to molecular modeling. This paper presents an approach to conformer generation that makes extensive use of the information available in the Cambridge Structural Database. By using geomet...
Databases, Protein Models, Molecular Knowledge Bases Ligands Software Algorithms Proteins Databases, Chemical Molecular Conformation Macrocyclic Compounds Hydrogen Bonding
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Computational Strategies for Dissecting the High-Dimensional Complexity of Adaptive Immune Repertoires.

Frontiers in immunology Feb 21, 2018
The adaptive immune system recognizes antigens an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interrogation of immune repertoires is of high relevance for understanding the adaptive immune response in...
Adaptive Immunity Data Interpretation, Statistical Autoimmune Diseases High-Throughput Nucleotide Sequencing Humans Receptors, Immunologic Machine Learning Neoplasms Software HIV Infections Animals Computational Biology Signal Transduction
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Using support vector machine analysis to assess PartinMR: A new prediction model for organ-confined prostate cancer.

Journal of magnetic resonance imaging : JMRI Feb 13, 2018
BACKGROUND: Partin tables represent the most widely used predictive tool for prostate cancer stage at prostatectomy but with potential limitations.
Humans Software Magnetic Resonance Imaging Area Under Curve Prostatic Neoplasms Algorithms Male Observer Variation Biopsy Retrospective Studies Proportional Hazards Models Middle Aged Reproducibility of Results Image Processing, Computer-Assisted Aged Support Vector Machine
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Evaluating Report Text Variation and Informativeness: Natural Language Processing of CT Chest Imaging for Pulmonary Embolism.

Journal of the American College of Radiology : JACR Feb 13, 2018
OBJECTIVE: The aim of this study was to quantify the variability of language in free text reports of pulmonary embolus (PE) studies and to gauge the informativeness of free text to predict PE diagnosis using machine learning as proxy for human unders...
Humans Machine Learning Natural Language Processing Pulmonary Embolism Data Mining Documentation Software Retrospective Studies Tomography, X-Ray Computed Contrast Media
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Classification of the Clinical Images for Benign and Malignant Cutaneous Tumors Using a Deep Learning Algorithm.

The Journal of investigative dermatology Feb 8, 2018
We tested the use of a deep learning algorithm to classify the clinical images of 12 skin diseases-basal cell carcinoma, squamous cell carcinoma, intraepithelial carcinoma, actinic keratosis, seborrheic keratosis, malignant melanoma, melanocytic nevu...
Keratosis, Seborrheic Warts Granuloma, Pyogenic Keratosis, Actinic Skin Datasets as Topic False Positive Reactions Photography Lentigo Middle Aged Deep Learning ROC Curve Image Processing, Computer-Assisted Diagnosis, Differential Predictive Value of Tests Area Under Curve Biopsy Female Skin Neoplasms Aged Humans Software Aged, 80 and over Young Adult Adult Male
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Deep learning with domain adaptation for accelerated projection-reconstruction MR.

Magnetic resonance in medicine Feb 4, 2018
Healthy Volunteers Fourier Analysis Deep Learning Image Processing, Computer-Assisted Magnetic Resonance Imaging Liver Humans Neural Networks, Computer Software Algorithms Tomography, X-Ray Computed Reproducibility of Results
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PREvaIL, an integrative approach for inferring catalytic residues using sequence, structural, and network features in a machine-learning framework.

Journal of theoretical biology Feb 1, 2018
Determining the catalytic residues in an enzyme is critical to our understanding the relationship between protein sequence, structure, function, and enhancing our ability to design novel enzymes and their inhibitors. Although many enzymes have been s...
Protein Conformation Sequence Analysis, Protein Machine Learning Software Databases, Protein Catalysis
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Prediction of GPCR-Ligand Binding Using Machine Learning Algorithms.

Computational and mathematical methods in medicine Jan 30, 2018
We propose a novel method that predicts binding of G-protein coupled receptors (GPCRs) and ligands. The proposed method uses hub and cycle structures of ligands and amino acid motif sequences of GPCRs, rather than the 3D structure of a receptor or si...
Receptors, G-Protein-Coupled Humans False Positive Reactions Machine Learning Binding Sites Area Under Curve Algorithms Software Amino Acid Motifs Quercetin Reproducibility of Results Sequence Analysis, Protein Ligands ROC Curve Protein Binding
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