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Classification and Verification of Handwritten Signatures with Time Causal Information Theory Quantifiers.

PloS one Dec 1, 2016
We present a new approach for handwritten signature classification and verification based on descriptors stemming from time causal information theory. The proposal uses the Shannon entropy, the statistical complexity, and the Fisher information evalu...
Information Theory Support Vector Machine Pattern Recognition, Automated Individuality Humans Software Biometry Entropy Handwriting
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Who Should Decide How Machines Make Morally Laden Decisions?

Science and engineering ethics Nov 30, 2016
Who should decide how a machine will decide what to do when it is driving a car, performing a medical procedure, or, more generally, when it is facing any kind of morally laden decision? More and more, machines are making complex decisions with a con...
Decision Making Artificial Intelligence Software
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Boosting Docking-Based Virtual Screening with Deep Learning.

Journal of chemical information and modeling Nov 29, 2016
In this work, we propose a deep learning approach to improve docking-based virtual screening. The deep neural network that is introduced, DeepVS, uses the output of a docking program and learns how to extract relevant features from basic data such as...
Software Algorithms Molecular Docking Simulation Proteins Computer-Aided Design Ligands Humans Drug Design Neural Networks, Computer ROC Curve
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The Human Phenotype Ontology in 2017.

Nucleic acids research Nov 28, 2016
Deep phenotyping has been defined as the precise and comprehensive analysis of phenotypic abnormalities in which the individual components of the phenotype are observed and described. The three components of the Human Phenotype Ontology (HPO; www.hum...
Genomics Genetic Association Studies Computational Biology Rare Diseases Translational Research, Biomedical Biological Ontologies Algorithms Humans Phenotype Software Precision Medicine
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Integrated Automatic Workflow for Phylogenetic Tree Analysis Using Public Access and Local Web Services.

Journal of integrative bioinformatics Nov 28, 2016
At the present, coding sequence (CDS) has been discovered and larger CDS is being revealed frequently. Approaches and related tools have also been developed and upgraded concurrently, especially for phylogenetic tree analysis. This paper proposes an ...
Internet Software Phylogeny Models, Genetic
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LBSizeCleav: improved support vector machine (SVM)-based prediction of Dicer cleavage sites using loop/bulge length.

BMC bioinformatics Nov 25, 2016
BACKGROUND: Dicer is necessary for the process of mature microRNA (miRNA) formation because the Dicer enzyme cleaves pre-miRNA correctly to generate miRNA with correct seed regions. Nonetheless, the mechanism underlying the selection of a Dicer cleav...
Nucleic Acid Conformation RNA Precursors MicroRNAs DEAD-box RNA Helicases Software Ribonuclease III Bayes Theorem Algorithms Support Vector Machine Base Sequence Humans
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Two-Way Regularized Fuzzy Clustering of Multiple Correspondence Analysis.

Multivariate behavioral research Nov 21, 2016
Multiple correspondence analysis (MCA) is a useful tool for investigating the interrelationships among dummy-coded categorical variables. MCA has been combined with clustering methods to examine whether there exist heterogeneous subclusters of a popu...
Politics Cluster Analysis Least-Squares Analysis Monte Carlo Method Computer Simulation Canada Fuzzy Logic Software Humans Algorithms
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Classification of Porcine Cranial Fracture Patterns Using a Fracture Printing Interface.

Journal of forensic sciences Nov 16, 2016
Distinguishing between accidental and abusive head trauma in children can be difficult, as there is a lack of baseline data for pediatric cranial fracture patterns. A porcine head model has recently been developed and utilized in a series of studies ...
Models, Animal Forensic Anthropology Child Abuse Diagnosis, Differential Skull Fractures Accidents Humans Machine Learning Swine Child Software Animals
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SNooPer: a machine learning-based method for somatic variant identification from low-pass next-generation sequencing.

BMC genomics Nov 14, 2016
BACKGROUND: Next-generation sequencing (NGS) allows unbiased, in-depth interrogation of cancer genomes. Many somatic variant callers have been developed yet accurate ascertainment of somatic variants remains a considerable challenge as evidenced by t...
Software Algorithms Reproducibility of Results Machine Learning Workflow Genetic Variation High-Throughput Nucleotide Sequencing Web Browser Polymorphism, Single Nucleotide Computational Biology Mutation
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Advanced literature analysis in a Big Data world.

Annals of the New York Academy of Sciences Nov 10, 2016
Comprehensive data mining of the scientific literature has become an increasing challenge. To address this challenge, Elsevier's Pathway Studio software uses the techniques of natural language processing to systematically extract specific biological ...
Biomarkers Prognosis Biomedical Research Animals Humans Software Mental Disorders Database Management Systems Databases, Bibliographic Natural Language Processing Periodicals as Topic Translational Research, Biomedical Abstracting and Indexing National Institute of Mental Health (U.S.) Schizophrenia Data Mining Computational Biology United States Mass Screening Depressive Disorder, Major Anxiety Disorders Bipolar Disorder
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