AIMC Topic: Staphylococcus aureus
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A Machine Learning-Based Risk Score for Prediction of Infective Endocarditis Among Patients With Staphylococcus aureus Bacteremia-The SABIER Score.
The Journal of infectious diseases
Sep 23, 2024
BACKGROUND: Early risk assessment is needed to stratify Staphylococcus aureus infective endocarditis (SA-IE) risk among patients with S. aureus bacteremia (SAB) to guide clinical management. The objective of the current study was to develop a novel r...
De novo synthetic antimicrobial peptide design with a recurrent neural network.
Protein science : a publication of the Protein Society
Aug 1, 2024
Antibiotic resistance is recognized as an imminent and growing global health threat. New antimicrobial drugs are urgently needed due to the decreasing effectiveness of conventional small-molecule antibiotics. Antimicrobial peptides (AMPs), a class of...
Biological activities of crude leaf extract and fractions of Scutellaria sibthorpii (Benth.) Halácsy: An endemic plant of North-Cyprus.
Pakistan journal of pharmaceutical sciences
Nov 1, 2023
Scutellaria sibthorpii is used in treatment of bacterial infections, pains and inflammations. The leaf was extracted by maceration and then partitioned with hexane, ethyl acetate and n-butanol. The extract was screened for phytochemicals. The antioxi...
iModulonDB: a knowledgebase of microbial transcriptional regulation derived from machine learning.
Nucleic acids research
Jan 8, 2021
Independent component analysis (ICA) of bacterial transcriptomes has emerged as a powerful tool for obtaining co-regulated, independently-modulated gene sets (iModulons), inferring their activities across a range of conditions, and enabling their ass...
Antimicrobial and synergistic activity of thiazoline derivatives in combination with conventional antibiotics against multidrug resistant Staphylococcus aureus isolated from abscess drainage samples.
Pakistan journal of pharmaceutical sciences
Sep 1, 2020
Emergence and spread of multidrug resistant (MDR) Staphylococcus aureus strains is becoming major challenge in treatment of soft tissue infections. This study aimed to explore antimicrobial and synergistic antimicrobial potential of three commerciall...
Anti-inflammatory and antibacterial activities of P. petiolosa (Christ) Ching ethyl acetate extract against S. aureus in mice.
Pakistan journal of pharmaceutical sciences
Sep 1, 2020
P. petiolosa as a typical Chinese herbal medicine has been generally utilized as Chinese native medicine formulation for treatment of chronic bronchitis, bronchial asthma and pneumoconiosis. The objective of this study was to evaluate the anti-inflam...
Anti-Inflammatory Agents
Acetates
Solvents
Bacterial Load
Heme Oxygenase-1
Anti-Bacterial Agents
Inflammation Mediators
Tumor Necrosis Factor-alpha
Nitric Oxide Synthase Type II
Animals
Staphylococcus aureus
Disease Models, Animal
Mice, Inbred BALB C
Lung
Plant Leaves
Pneumonia, Staphylococcal
Plant Extracts
Polypodiaceae
Membrane Proteins
Studies for Bacterystic Evaluation against of 2-Naphthoic Acid Analogues.
Current topics in medicinal chemistry
Jan 1, 2020
BACKGROUND: Staphylococcus aureus is a gram-positive spherical bacterium commonly present in nasal fossae and in the skin of healthy people; however, in high quantities, it can lead to complications that compromise health. The pathologies involved in...
Phytochemical screening, antioxidant and antibacterial properties of daphne mucronata.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
Dec 1, 2019
OBJECTIVE: To aim at preliminary phytochemical screening of Daphne mucronata and evaluate its antioxidant and antibacterial activities.
High-throughput screening and Bayesian machine learning for copper-dependent inhibitors of Staphylococcus aureus.
Metallomics : integrated biometal science
Mar 20, 2019
One potential source of new antibacterials is through probing existing chemical libraries for copper-dependent inhibitors (CDIs), i.e., molecules with antibiotic activity only in the presence of copper. Recently, our group demonstrated that previousl...
Bacillus methylotrophicus ASWU-C2, a strain inhabiting hot desert soil, a new source for antibacterial bacillopyrone, pyrophen, and cyclopeptides.
Zeitschrift fur Naturforschung. C, Journal of biosciences
Dec 19, 2018
A strain of Bacillus methylotrophicus was isolated from a soil sample collected in Aswan eastern desert, which is known for its extremely arid climate. After fermentation of the strain in liquid culture and subsequent extraction, a bioassay-guided is...
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