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Synaptic Transmission

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Neuronify: An Educational Simulator for Neural Circuits.

eNeuro
Educational software (apps) can improve science education by providing an interactive way of learning about complicated topics that are hard to explain with text and static illustrations. However, few educational apps are available for simulation of ...

Synaptic damage underlies EEG abnormalities in postanoxic encephalopathy: A computational study.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
OBJECTIVE: In postanoxic coma, EEG patterns indicate the severity of encephalopathy and typically evolve in time. We aim to improve the understanding of pathophysiological mechanisms underlying these EEG abnormalities.

Global and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway.

Scientific reports
The cortico-striatal-thalamo-cortical (CSTC) pathway is a brain circuit that controls movement execution, habit formation and reward. Hyperactivity in the CSTC pathway is involved in obsessive compulsive disorder (OCD), a neuropsychiatric disorder ch...

Synaptic convergence regulates synchronization-dependent spike transfer in feedforward neural networks.

Journal of computational neuroscience
Correlated neural activities such as synchronizations can significantly alter the characteristics of spike transfer between neural layers. However, it is not clear how this synchronization-dependent spike transfer can be affected by the structure of ...

Working Memory and Decision-Making in a Frontoparietal Circuit Model.

The Journal of neuroscience : the official journal of the Society for Neuroscience
Working memory (WM) and decision-making (DM) are fundamental cognitive functions involving a distributed interacting network of brain areas, with the posterior parietal cortex (PPC) and prefrontal cortex (PFC) at the core. However, the shared and dis...

Propagation delays determine neuronal activity and synaptic connectivity patterns emerging in plastic neuronal networks.

Chaos (Woodbury, N.Y.)
In plastic neuronal networks, the synaptic strengths are adapted to the neuronal activity. Specifically, spike-timing-dependent plasticity (STDP) is a fundamental mechanism that modifies the synaptic strengths based on the relative timing of pre- and...

Global firing rate contrast enhancement in E/I neuronal networks by recurrent synchronized inhibition.

Chaos (Woodbury, N.Y.)
Inhibitory synchronization is commonly observed and may play some important functional roles in excitatory/inhibitory (E/I) neuronal networks. The firing rate contrast enhancement is a general feature of information processing in sensory pathways, an...

Memristive Imitation of Synaptic Transmission and Plasticity.

IEEE transactions on neural networks and learning systems
In this paper, a memristive artificial neural circuit imitating the excitatory chemical synaptic transmission of biological synapse is designed. The proposed memristor-based neural circuit exhibits synaptic plasticity, one of the important neurochemi...

DoGNet: A deep architecture for synapse detection in multiplexed fluorescence images.

PLoS computational biology
Neuronal synapses transmit electrochemical signals between cells through the coordinated action of presynaptic vesicles, ion channels, scaffolding and adapter proteins, and membrane receptors. In situ structural characterization of numerous synaptic ...

Mutual Inhibition with Few Inhibitory Cells via Nonlinear Inhibitory Synaptic Interaction.

Neural computation
In computational neural network models, neurons are usually allowed to excite some and inhibit other neurons, depending on the weight of their synaptic connections. The traditional way to transform such networks into networks that obey Dale's law (i....