AIMC Topic: Tandem Mass Spectrometry
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Robotic-assisted dynamic large drop microextraction.
Journal of chromatography. A
Aug 11, 2019
By proper design of an innovative extraction device, a lab-made multipurpose autosampler was exploited in the automated performance of the dynamic large drops based microextraction. The pluses of this new analytical strategy were demonstrated in the ...
Serum N-Glycosylation in Parkinson's Disease: A Novel Approach for Potential Alterations.
Molecules (Basel, Switzerland)
Jun 13, 2019
In this study, we present the application of a novel capillary electrophoresis (CE) method in combination with label-free quantitation and support vector machine-based feature selection (support vector machine-estimated recursive feature elimination ...
Prosit: proteome-wide prediction of peptide tandem mass spectra by deep learning.
Nature methods
May 27, 2019
In mass-spectrometry-based proteomics, the identification and quantification of peptides and proteins heavily rely on sequence database searching or spectral library matching. The lack of accurate predictive models for fragment ion intensities impair...
Identification of the lipid-lowering component of triterpenes from Alismatis rhizoma based on the MRM-based characteristic chemical profiles and support vector machine model.
Analytical and bioanalytical chemistry
May 14, 2019
It has been demonstrated that triterpenes in Alismatis rhizoma (Zexie in Chinese, ZX) contributed to the lipid-lowering effect on high-fat diet-induced hyperlipidemia. Alisol B 23-acetate, one of the abundant triterpenes in ZX, was used as the marker...
Biochemical, machine learning and molecular approaches for the differential diagnosis of Mucopolysaccharidoses.
Molecular and cellular biochemistry
Mar 21, 2019
This study was aimed to construct classification and regression tree (CART) model of glycosaminoglycans (GAGs) for the differential diagnosis of Mucopolysaccharidoses (MPS). Two-dimensional electrophoresis and liquid chromatography-tandem mass spectr...
Quantitation of serum 25(OH)D2 and 25(OH)D3 concentrations by liquid chromatography tandem mass spectrometry in patients with diabetes mellitus.
Journal of food and drug analysis
Dec 31, 2018
Vitamin D has been considered to regulate calcium and phosphorus homeostasis and to preserve skeletal integrity. Serum 25-hydroxyvitamin D (25(OH)D) is the best indicator of vitamin D levels. The association of serum 25(OH)D deficiency with increased...
Development and validation of a sensitive method for alkyl sulfonate genotoxic impurities determination in drug substances using gas chromatography coupled to triple quadrupole mass spectrometry.
Journal of pharmaceutical and biomedical analysis
Dec 30, 2018
Alkyl sulfonate esters have been widely concerned as genotoxic impurities (GTIs). A gas chromatography triple-quadrupole mass spectrometry (GC-MS/MS) method has been developed for trace determination of 9 commonly encountered sulfonate esters in drug...
BPA, BADGE and analogues: A new multi-analyte LC-ESI-MS/MS method for their determination and their in vitro (anti)estrogenic and (anti)androgenic properties.
Chemosphere
Dec 28, 2018
Information on the occurrence and endocrine potencies of analogues of bisphenol A (BPA) and diglycidyl ester derivatives (BDGEs) of BPA and BPF is limited. Such information is, however, important as the current debate on BPA and the lowered BPA migra...
Rapid LC-MS/MS quantification of cancer related acetylated polyamines in human biofluids.
Talanta
Dec 26, 2018
Increased urinary acetylated polyamines (APs) are reported as cancer biomarkers in many studies. N,N-diacetylspermine has been proposed as a biomarker indicative of different cancers in urine and plasma. N-Acetylspermine has previously been found to ...
Decomposition Kinetics of Omethoate in Blood.
Fa yi xue za zhi
Dec 25, 2018
OBJECTIVES: To study the decomposition kinetics of omethoate in blood.
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