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Tissue Engineering

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Design and optimization of tamarind seed polysaccharide-based scaffold for tissue engineering applications using statistical modeling and machine learning, and it's in-vitro validation.

International journal of biological macromolecules
This study explores the development and optimization of a novel biomaterial scaffold for tissue engineering, composed of Tamarind seed polysaccharide (TSP), Hydroxypropyl methylcellulose (HPMC), Chitosan (CS), and Sodium alginate (ALG). Scaffold prop...

A spatiotemporal and machine-learning platform facilitates the manufacturing of hPSC-derived esophageal mucosa.

Developmental cell
Human pluripotent stem cell-derived tissue engineering offers great promise for designer cell-based personalized therapeutics, but harnessing such potential requires a deeper understanding of tissue-level interactions. We previously developed a cell ...

Optimizing the value of bioinks and robotics to advance in vivo bioprinting.

Current opinion in biotechnology
In vivo bioprinting strategies aim at facilitating immediate integration of engineered tissues with the host's biological system. As integral parts of current bioprinting technologies, bioinks and robotics should be holistically considered for new bi...

Advancing regenerative medicine: the Aceman system's pioneering automation and machine learning in mesenchymal stem cell biofabrication.

Biofabrication
Mesenchymal stem cells (MSCs) are pivotal in advancing regenerative medicine; however, the large-scale production of MSCs for clinical applications faces significant challenges related to efficiency, cost, and quality assurance. We introduce the Auto...

Bioinspired design of a tissue-engineered ray with machine learning.

Science robotics
In biomimetic design, researchers recreate existing biological structures to form functional devices. For biohybrid robotic swimmers assembled with tissue engineering, this is problematic because most devices operate at different length scales than t...

Soft Biological Actuators for Meter-Scale Homeostatic Biohybrid Robots.

Chemical reviews
Skeletal muscle's elegant protein-based architecture powers motion throughout the animal kingdom, with its constituent actomyosin complexes driving intra- and extra-cellular motion. Classical motors and recently developed soft actuators cannot match ...

Predicting inflammatory response of biomimetic nanofibre scaffolds for tissue regeneration using machine learning and graph theory.

Journal of materials chemistry. B
Tissue regeneration after a wound occurs through three main overlapping and interrelated stages namely inflammatory, proliferative, and remodelling phases, respectively. The inflammatory phase is key for successful tissue reconstruction and triggers ...

Optimal structural characteristics of osteoinductivity in bioceramics derived from a novel high-throughput screening plus machine learning approach.

Biomaterials
Osteoinduction is an important feature of the next generation of bone repair materials. But the key structural factors and parameters of osteoinductive scaffolds are not yet clarified. This study leverages the efficiency of high-throughput screening ...

Surrogate modeling of electrospun PVA/PLA nanofibers using artificial neural network for biomedical applications.

Scientific reports
Blending poly (lactic acid) (PLA) with poly (vinyl alcohol) (PVA) improves the strength and hydrophilicity of nanofibers, making them suitable for biomedical applications like wound dressings. This study explores how electrospinning parameters-applie...

What insights can spatiotemporal esophageal atlases and deep learning bring to engineering the esophageal mucosa?

Developmental cell
In this issue of Developmental Cell, Yang et al. present an integrated experimental and computational platform that maps the spatiotemporal development of the human esophagus and predicts key signaling pathways governing epithelial differentiation. T...