AIMC Topic: Transcriptome

Clear Filters Showing 971 to 980 of 1041 articles

Deep centroid: a general deep cascade classifier for biomedical omics data classification.

Bioinformatics (Oxford, England)
MOTIVATION: Classification of samples using biomedical omics data is a widely used method in biomedical research. However, these datasets often possess challenging characteristics, including high dimensionality, limited sample sizes, and inherent bia...

Integration of transcriptome and machine learning to identify the potential key genes and regulatory networks affecting drip loss in pork.

Journal of animal science
Low level of drip loss (DL) is an important quality characteristic of meat with high economic value. However, the key genes and regulatory networks contributing to DL in pork remain largely unknown. To accurately identify the key genes affecting DL i...

spatiAlign: an unsupervised contrastive learning model for data integration of spatially resolved transcriptomics.

GigaScience
BACKGROUND: Integrative analysis of spatially resolved transcriptomics datasets empowers a deeper understanding of complex biological systems. However, integrating multiple tissue sections presents challenges for batch effect removal, particularly wh...

Molecular characterization, immunocorrelation analysis, WGCNA analysis and machine learning modeling of genes associated with copper death subtypes of laryngeal cancer.

Technology and health care : official journal of the European Society for Engineering and Medicine
BACKGROUND: Laryngeal cancer is a malignant tumor that originates from the mucous membrane of the larynx. Currently, the specific involvement mechanism of copper death in laryngeal cancer patients has not been deeply studied.

Insights into a Machine Learning-Based Palmitoylation-Related Gene Model for Predicting the Prognosis and Treatment Response of Breast Cancer Patients.

Technology in cancer research & treatment
BACKGROUND: Breast cancer is a prevalent public health concern affecting numerous women globally and is associated with palmitoylation, a post-translational protein modification. Despite increasing focus on palmitoylation, its specific implications f...

Machine Learning Identify Ferroptosis-Related Genes as Potential Diagnostic Biomarkers for Gastric Intestinal Metaplasia.

Technology in cancer research & treatment
BACKGROUND: Gastric intestinal metaplasia(GIM) is an independent risk factor for GC, however, its pathogenesis is still unclear. Ferroptosis is a new type of programmed cell death, which may be involved in the process of GIM. The purpose of this stud...

Screening Targets and Therapeutic Drugs for Alzheimer's Disease Based on Deep Learning Model and Molecular Docking.

Journal of Alzheimer's disease : JAD
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder caused by a complex interplay of various factors. However, a satisfactory cure for AD remains elusive. Pharmacological interventions based on drug targets are considered the most co...

[Omics and cell controlling technology for drug discovery].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Knowledge Palette, Inc. is a start-up company that aims to overcome incurable diseases by applying the world's most accurate single-cell level and bulk level transcriptome technology to obtain large-scale data on the state of cells treated with vario...

Patterns of Gene Expression Profiles Associated with Colorectal Cancer in Colorectal Mucosa by Using Machine Learning Methods.

Combinatorial chemistry & high throughput screening
BACKGROUND: Colorectal cancer (CRC) has a very high incidence and lethality rate and is one of the most dangerous cancer types. Timely diagnosis can effectively reduce the incidence of colorectal cancer. Changes in para-cancerous tissues may serve as...