AIMC Topic: Warfarin

Clear Filters Showing 11 to 20 of 24 articles

An Ensemble Model With Clustering Assumption for Warfarin Dose Prediction in Chinese Patients.

IEEE journal of biomedical and health informatics Jan 7, 2019
The prediction of daily stable warfarin dosage for a specific patient is difficult. To improve the predictive accuracy and to build a highly accurate predictive model, we developed an ensemble learning method, called evolutionary fuzzy c-mean (EFCM) ...
Algorithms China Fuzzy Logic Cluster Analysis Models, Statistical Warfarin Humans Neural Networks, Computer
View on PubMed DOI

Ensemble of machine learning algorithms using the stacked generalization approach to estimate the warfarin dose.

PloS one Oct 19, 2018
Warfarin dosing remains challenging due to narrow therapeutic index and highly individual variability. Incorrect warfarin dosing is associated with devastating adverse events. Remarkable efforts have been made to develop the machine learning based wa...
Humans Machine Learning Genotype Algorithms Male Linkage Disequilibrium Drug Administration Schedule Databases, Factual Anticoagulants Middle Aged Medical Errors Multivariate Analysis Female Pharmacogenetics Warfarin Vitamin K Epoxide Reductases International Cooperation Aged Cohort Studies Thrombosis Aged, 80 and over Polymorphism, Single Nucleotide Hemorrhage
View on PubMed DOI

A prediction study of warfarin individual stable dose after mechanical heart valve replacement: adaptive neural-fuzzy inference system prediction.

BMC surgery Feb 15, 2018
BACKGROUND: It's difficult but urgent to achieve the individualized rational medication of the warfarin, we aim to predict the individualized warfarin stable dose though the artificial intelligent Adaptive neural-fuzzy inference system (ANFIS).
Male Middle Aged China Fuzzy Logic Anticoagulants Humans Neural Networks, Computer Retrospective Studies Female Reproducibility of Results Warfarin Heart Valve Prosthesis Implantation Linear Models
View on PubMed DOI

A Comparative Study of Point-of-Care Prothrombin Time in Cardiopulmonary Bypass Surgery.

Journal of cardiothoracic and vascular anesthesia Dec 29, 2017
OBJECTIVE: Point-of-care (POC) devices allow for prothrombin time/international normalized ratio (PT/INR) testing in whole blood (WB) and timely administration of plasma or prothrombin complex concentrate during cardiopulmonary bypass surgery. This s...
Warfarin Male Humans International Normalized Ratio Point-of-Care Systems Prospective Studies Cardiopulmonary Bypass Middle Aged Female Prothrombin Time Monitoring, Intraoperative Young Adult Anticoagulants Adult
View on PubMed DOI

Identifying Drug-Drug Interactions by Data Mining: A Pilot Study of Warfarin-Associated Drug Interactions.

Circulation. Cardiovascular quality and outcomes Nov 8, 2016
BACKGROUND: Knowledge about drug-drug interactions commonly arises from preclinical trials, from adverse drug reports, or based on knowledge of mechanisms of action. Our aim was to investigate whether drug-drug interactions were discoverable without ...
Anticoagulants Blood Coagulation Warfarin Humans International Normalized Ratio Registries Machine Learning Aged, 80 and over Retrospective Studies Male Drug Interactions Female Pilot Projects Data Mining Polypharmacy Risk Factors Logistic Models Atrial Fibrillation Aged Predictive Value of Tests Drug Prescriptions Administrative Claims, Healthcare
View on PubMed DOI

Incidence of severe renal dysfunction among individuals taking warfarin and implications for non-vitamin K oral anticoagulants.

American heart journal Nov 4, 2016
BACKGROUND: The purpose of this study is to assess incidence and risk factors for severe renal dysfunction in patients requiring oral anticoagulation to help guide initial drug choice and provide a rational basis for interval monitoring of renal func...
Creatinine Atrial Fibrillation Multivariate Analysis Odds Ratio Kaplan-Meier Estimate Age Factors Anticoagulants Warfarin Middle Aged Coronary Artery Disease Severity of Illness Index Humans Stroke Incidence Female Risk Factors Logistic Models Aged Renal Insufficiency, Chronic Male
View on PubMed DOI

Development of neuro-fuzzy model to explore gene-nutrient interactions modulating warfarin dose requirement.

Pharmacogenomics Jul 27, 2016
AIM: To investigate the influence of alterations in vitamin K (K1, K2 and K3) in modulating warfarin dose requirement.
Adult Male Middle Aged Adolescent Child Humans Female Aged Young Adult Asian People Genetic Variation Vitamin K Polymorphism, Genetic Genotype Fuzzy Logic Models, Neurological Anticoagulants Warfarin
View on PubMed DOI

Artificial neural network-based pharmacogenomic algorithm for warfarin dose optimization.

Pharmacogenomics Dec 15, 2015
AIM: To develop more precise pharmacogenomic algorithm for prediction of safe and effective dose of warfarin.
Cytochrome P-450 CYP2C9 Algorithms Female Young Adult Adult Male Middle Aged Anticoagulants Warfarin Models, Biological Stereoisomerism Humans Neural Networks, Computer
View on PubMed DOI

Edoxaban vs warfarin in patients with nonvalvular atrial fibrillation in the US Food and Drug Administration approval population: An analysis from the Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48 (ENGAGE AF-TIMI 48) trial.

American heart journal Dec 1, 2015
BACKGROUND: Edoxaban is a specific anti-Xa inhibitor that, in comparison to warfarin, has been found to be noninferior for the prevention of stroke or systemic embolism (SSE) and to reduce bleeding significantly in patients with nonvalvular atrial fi...
Male United States Dose-Response Relationship, Drug Humans Female Aged Thiazoles Factor Xa Factor Xa Inhibitors Drug Approval Warfarin Stroke Myocardial Infarction Atrial Fibrillation United States Food and Drug Administration Pyridines Thrombolytic Therapy Anticoagulants Blood Coagulation Double-Blind Method
View on PubMed DOI

Revisiting Warfarin Dosing Using Machine Learning Techniques.

Computational and mathematical methods in medicine Jun 4, 2015
Determining the appropriate dosage of warfarin is an important yet challenging task. Several prediction models have been proposed to estimate a therapeutic dose for patients. The models are either clinical models which contain clinical and demographi...
Warfarin Drug Administration Schedule Humans False Positive Reactions Female Machine Learning Pharmacogenetics Reproducibility of Results Algorithms Genotype Male Databases, Factual Dose-Response Relationship, Drug Regression Analysis Anticoagulants
View on PubMed DOI
Popular Topics
Recent Journals