Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jan 17, 2025
Circular RNAs in extracellular vesicles (EV-circRNAs) are gaining recognition as potential biomarkers for the diagnosis of gastric cancer (GC). Most current research is focused on identifying new biomarkers and their functional significance in diseas...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jan 15, 2025
Urinalysis is one of the predominant tools for clinical testing owing to the abundant composition, sufficient volume, and non-invasive acquisition of urine. As a critical component of routine urinalysis, urine protein testing measures the levels and ...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jan 13, 2025
Protein phosphorylation plays a crucial role in regulating a wide range of biological processes, and its dysregulation is strongly linked to various diseases. While many phosphorylation sites have been identified so far, their functionality and regul...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jan 10, 2025
Small molecules as nanomedicine carriers offer advantages in drug loading and preparation. Selecting effective small molecules for stable nanomedicines is challenging. This study used artificial intelligence (AI) to screen drug combinations for self-...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jan 10, 2025
Human epidermal growth factor receptor 2 (HER2) positive gastric cancer (GC) shows a robust response to the combined therapy based HER2-targeted therapy. The application of these therapies is highly dependent on the evaluation of tumor HER2 status. H...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jan 7, 2025
Mass spectrometry imaging (MSI) provides valuable insights into metabolic heterogeneity by capturing in situ molecular profiles within organisms. One challenge of MSI heterogeneity analysis is performing an objective segmentation to differentiate the...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jan 7, 2025
Human-machine interfaces and wearable electronics, as fundamentals to achieve human-machine interactions, are becoming increasingly essential in the era of the Internet of Things. However, contemporary wearable sensors based on resistive and capaciti...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Dec 31, 2024
The patch clamp technique is a fundamental tool for investigating ion channel dynamics and electrophysiological properties. This study proposes the first artificial intelligence framework for characterizing multiple ion channel kinetics of whole-cell...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Dec 31, 2024
Moyamoya disease (MMD) is a progressive cerebrovascular disorder that increases the risk of intracranial ischemia and hemorrhage. Timely diagnosis and intervention can significantly reduce the risk of new-onset stroke in patients with MMD. However, t...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Dec 27, 2024
Hemodynamic stabilization is crucial in managing acute cardiac events, where compromised blood flow can lead to severe complications and increased mortality. Conditions like decompensated heart failure (HF) and cardiogenic shock require rapid and eff...