Laboratory investigation; a journal of technical methods and pathology
May 7, 2025
Molecular subtyping of pulmonary large cell neuroendocrine carcinoma (LCNEC) based on retinoblastoma protein (pRb) expression may influence systemic treatment decisions. Current histomorphological assessments of hematoxylin and eosin (H&E)-stained ti...
Laboratory investigation; a journal of technical methods and pathology
Feb 12, 2025
Quality control of immunohistochemistry (IHC) slides is crucial to ascertain accurate patient management. Visual assessment is the most commonly used method to assess the quality of IHC slides from patient samples in daily pathology routines. Control...
Laboratory investigation; a journal of technical methods and pathology
Jan 16, 2025
The tumor microenvironment plays a critical role in cancer progression and therapeutic responsiveness, with the tumor immune microenvironment (TIME) being a key modulator. In head and neck squamous cell carcinomas (HNSCCs), immune cell infiltration s...
Laboratory investigation; a journal of technical methods and pathology
Dec 26, 2024
Tumor cell nuclear size (NS) indicates malignant potential in breast cancer; however, its clinical significance in esophageal squamous cell carcinoma (ESCC) is unknown. Artificial intelligence (AI) can quantitatively evaluate histopathological findin...
Laboratory investigation; a journal of technical methods and pathology
Dec 13, 2024
Interstitial lung disease (ILD), characterized by inflammation and fibrosis, often suffers from low diagnostic accuracy and consistency. Traditional hematoxylin and eosin (H&E) staining primarily reveals cellular inflammation with limited detail on f...
Laboratory investigation; a journal of technical methods and pathology
Nov 29, 2024
Integrating digital pathology and artificial intelligence (AI) algorithms can potentially improve diagnostic practice and precision medicine. Developing reliable, generalizable, and comparable AI algorithms depends on access to meticulously annotated...
Laboratory investigation; a journal of technical methods and pathology
Nov 20, 2024
Hirschsprung disease, a congenital disease characterized by the absence of ganglion cells, presents significant surgical challenges. Addressing a critical gap in intraoperative diagnostics, we introduce transformative artificial intelligence approach...
Laboratory investigation; a journal of technical methods and pathology
Nov 13, 2024
Lung squamous cell carcinoma (LUSC), a subtype of non-small cell lung cancer, represents a significant portion of lung cancer cases with distinct histologic patterns impacting prognosis and treatment. The current pathological assessment methods face ...
Laboratory investigation; a journal of technical methods and pathology
Nov 9, 2024
Accurate whole-cell segmentation is essential in various biomedical applications, particularly in studying the tumor microenvironment. Despite advancements in machine learning for nuclei segmentation in hematoxylin and eosin (H&E)-stained images, the...
Laboratory investigation; a journal of technical methods and pathology
Sep 2, 2024
In digital pathology, accurate mitosis detection in histopathological images is critical for cancer diagnosis and prognosis. However, this remains challenging due to the inherent variability in cell morphology and the domain shift problem. This study...