The Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses through semantic similar...
BACKGROUND: Exploring the cellular processes of genes from the aspects of biological networks is of great interest to understanding the properties of complex diseases and biological systems. Biological networks, such as protein-protein interaction ne...
BACKGROUND: Due to a constant evolutionary arms race, archaea and bacteria have evolved an abundance and diversity of immune responses to protect themselves against phages. Since the discovery and application of CRISPR-Cas adaptive immune systems, nu...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Jan 1, 2024
In this study, we explore a natural language processing (NLP) algorithm's capacity to identify proximal but distinct suicide attempt (SA) events compared to diagnostic code-based approaches. This study used an NLP algorithm with high precision in ide...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Jan 1, 2024
This study evaluates the utility of machine learning (ML) algorithms in early forecasting of total symptom score changes from daily self-reports of 339 chemotherapy patients. The dataset comprised 12 specific symptoms, with severity and distress for ...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Jan 1, 2024
This study introduces a groundbreaking approach to early cancer detection through the analysis of cell-free DNA (cfDNA), utilizing machine learning algorithms to navigate the complexities of low circulating tumor DNA (ctDNA) fractions and genetic het...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Jan 1, 2024
Epilepsy affects over 50 million persons worldwide, with less than 50% achieving long-term success following surgery. Traditional electrophysiology signal-based seizure detection methods are resource-intensive, laborious, and overlook multifocal brai...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Jan 1, 2024
The aim of this work was to create a gold-standard curated cohort of 10,000+ cases from the Veteran Affairs (VA) corporate data warehouse (CDW) for virtual emulation of a randomized clinical trial (CSP#592). The trial had six inclusion/exclusion crit...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Jan 1, 2024
Collecting images of rare dermatological diseases for machine learning detection applications is a costly, laborious task. It is difficult to collect enough images of these diagnoses to avoid the risk of low accuracy "in the wild". One of the sources...
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