This study developed machine learning models to predict Aβ positivity in Alzheimer's disease by integrating early-phase F-Florbetaben PET and clinical data to improve diagnostic accuracy. Furthermore, the study explored machine learning models to pre...
Proteases recognize substrates by decoding sequence information-an essential cellular process elusive when recognition motifs are absent. Here, we unravel this problem for γ-secretase, an intramembrane-cleaving protease associated with Alzheimer's di...
The current depth of site-specific N-glycoproteomics is insufficient to fully characterize glycosylation events in biological samples. Herein, we achieve an ultradeep and precision analysis of the N-glycoproteome of mouse tissues by integrating multi...
The journal of prevention of Alzheimer's disease
Jun 28, 2025
BACKGROUND: Alzheimer's disease (AD) is the most common form of dementia, and early diagnosis is crucial to enable effective interventions. Currently, Alzheimer's disease is diagnosed through cognitive assessments, brain imaging and fluid biomarkers ...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a gradual decline in cognitive ability and memory function. It is a progressive disease characterized by worsening dementia symptoms over time, starting with mild m...
BACKGROUND: Cuproptosis is increasingly recognized as an essential factor in the pathological process of Alzheimer's disease (AD). However, the specific role of cuproptosis-related genes in AD remains poorly understood.
Signal transduction and targeted therapy
Jun 23, 2025
Traumatic brain injury (TBI) is a major public health concern associated with an increased risk of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and chronic traumatic encephalopathy, yet the underlying molec...
BACKGROUND: Automated whole-brain delineation (WBD) techniques often struggle to generalize across pre-clinical studies due to variations in animal models, magnetic resonance imaging (MRI) scanners, and tissue contrasts. We developed a 3D U-Net neura...
Galectin-3 (Gal-3) has emerged as a critical regulator of neuroinflammation and a promising therapeutic target for Alzheimer's disease (AD). Nevertheless, the development of brain-penetrant small-molecule Gal-3 inhibitors poses a significant challeng...
BACKGROUND: Widely used in oncology PET, 2-deoxy-2- 18 F-FDG PET is more accessible and affordable than amyloid PET, which is a crucial tool to determine amyloid positivity in diagnosis of Alzheimer disease (AD). This study aimed to leverage deep lea...
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