AIMC Topic: Amides
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Unsupervised learning for magnetization transfer contrast MR fingerprinting: Application to CEST and nuclear Overhauser enhancement imaging.
Magnetic resonance in medicine
Oct 31, 2020
PURPOSE: To develop a fast, quantitative 3D magnetization transfer contrast (MTC) framework based on an unsupervised learning scheme, which will provide baseline reference signals for CEST and nuclear Overhauser enhancement imaging.
A Machine Learning Protocol for Predicting Protein Infrared Spectra.
Journal of the American Chemical Society
Oct 30, 2020
Infrared (IR) absorption provides important chemical fingerprints of biomolecules. Protein secondary structure determination from IR spectra is tedious since its theoretical interpretation requires repeated expensive quantum-mechanical calculations i...
Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity.
European journal of medicinal chemistry
Jan 31, 2018
Primaquine (PQ) is a commonly used drug that can prevent the transmission of Plasmodium falciparum malaria, however toxicity limits its use. We prepared five groups of PQ derivatives: amides 1a-k, ureas 2a-k, semicarbazides 3a,b, acylsemicarbazides 4...
2-methyl butyramide, a previously identified urine biomarker for Ascaris lumbricoides, is not present in infected Indonesian individuals.
Parasites & vectors
Dec 29, 2017
UNLABELLED: ᅟ: Previous reports suggest that the 2-methyl butyramide and 2-methyl valeramide metabolites of Ascaris lumbricoides in urine of infected individuals could be considered as urinary biomarkers for active infection. We have developed an LC-...
Protein asparagine deamidation prediction based on structures with machine learning methods.
PloS one
Jul 21, 2017
Chemical stability is a major concern in the development of protein therapeutics due to its impact on both efficacy and safety. Protein "hotspots" are amino acid residues that are subject to various chemical modifications, including deamidation, isom...
Simultaneous determination of four amides in Saururus chinensis by matrix solid phase dispersion and high-performance liquid chromatography method.
Journal of food and drug analysis
Apr 19, 2017
A rapid and simple analytical method was established for the determination of four amides (N-p-trans-coumaroyltyramine, aristolactam AⅡ, sauristolactam and aristolactam BⅡ) in Saururus chinensis by matrix solid phase dispersion (MSPD) and high-perfor...
Comparison of ropivacaine with and without fentanyl vs bupivacaine with fentanyl for postoperative epidural analgesia in bilateral total knee replacement surgery.
Journal of clinical anesthesia
Dec 22, 2016
STUDY OBJECTIVES: Pain after total knee replacement (TKR) interferes with early rehabilitation. Although the use of epidural bupivacaine in post-TKR patients is associated with effective analgesia, the associated motor blockade effect delays function...
Patient Satisfaction
Nausea
Analgesia, Epidural
Osteoarthritis
Analgesia, Patient-Controlled
Arthroplasty, Replacement, Knee
Pain Management
Bupivacaine
Ropivacaine
Analgesics, Opioid
Fentanyl
Female
Aged
Male
Anesthetics, Local
Humans
Treatment Outcome
Middle Aged
Pain Measurement
Prospective Studies
Drug Combinations
Double-Blind Method
Amides
Pain, Postoperative
Postoperative Care
Transversus abdominis plane (TAP) block after robot-assisted laparoscopic hysterectomy: a randomised clinical trial.
Acta anaesthesiologica Scandinavica
May 31, 2015
BACKGROUND: Transversus abdominis plane (TAP) block is widely used as a part of pain management after various abdominal surgeries. We evaluated the effect of TAP block as an add-on to the routine analgesic regimen in patients undergoing robot-assiste...
A deep learning framework for reconstructing Breast Amide Proton Transfer weighted imaging sequences from sparse frequency offsets to dense frequency offsets.
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Jul 1, 2025
Amide Proton Transfer (APT) technique is a novel functional MRI technique that enables quantification of protein metabolism, but its wide application is largely limited in clinical settings by its long acquisition time. One way to reduce the scanning...
Determination of Novel SARS-CoV-2 Inhibitors by Combination of Machine Learning and Molecular Modeling Methods.
Medicinal chemistry (Shariqah (United Arab Emirates))
Jan 1, 2024
INTRODUCTION: Within the scope of the project, this study aimed to find novel inhibitors by combining computational methods. In order to design inhibitors, it was aimed to produce molecules similar to the RdRp inhibitor drug Favipiravir by using the ...
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