AIMC Topic: Animals

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Resveratrol in animal models of pancreatitis and pancreatic cancer: A systematic review with machine learning.

Phytomedicine : international journal of phytotherapy and phytopharmacology
BACKGROUND: Resveratrol (RES), a common type of plant polyphenols, has demonstrated promising therapeutic efficacy and safety in animal models of pancreatitis and pancreatic cancer. However, a comprehensive analysis of these data is currently unavail...

A new era of psoriasis treatment: Drug repurposing through the lens of nanotechnology and machine learning.

International journal of pharmaceutics
Psoriasis is a persistent inflammatory skin disorder characterized by hyper-proliferation and abnormal epidermal differentiation. Conventional treatments such as; topical therapies, phototherapy, systemic immune modulators, and biologics aim to relie...

Deep Learning-Based Tumor Segmentation of Murine Magnetic Resonance Images of Prostate Cancer Patient-Derived Xenografts.

Tomography (Ann Arbor, Mich.)
BACKGROUND/OBJECTIVE: Longitudinal in vivo studies of murine xenograft models are widely utilized in oncology to study cancer biology and develop therapies. Magnetic resonance imaging (MRI) of these tumors is an invaluable tool for monitoring tumor g...

Identification of UBE2N as a biomarker of Alzheimer's disease by combining WGCNA with machine learning algorithms.

Scientific reports
Alzheimer's disease (AD) is the most common cause of dementia, emphasizing the critical need for the development of biomarkers that facilitate accurate and objective assessment of disease progression for early detection and intervention to delay its ...

Improving Malaria diagnosis through interpretable customized CNNs architectures.

Scientific reports
Malaria, which is spread via female Anopheles mosquitoes and is brought on by the Plasmodium parasite, persists as a serious illness, especially in areas with a high mosquito density. Traditional detection techniques, like examining blood samples wit...

Event-driven figure-ground organisation model for the humanoid robot iCub.

Nature communications
Figure-ground organisation is a perceptual grouping mechanism for detecting objects and boundaries, essential for an agent interacting with the environment. Current figure-ground segmentation methods rely on classical computer vision or deep learning...

Inhibition of CDC27 O-GlcNAcylation coordinates the antitumor efficacy in multiple myeloma through the autophagy-lysosome pathway.

Acta pharmacologica Sinica
Multiple myeloma (MM) is a prevalent hematologic malignancy characterized by abnormal proliferation of cloned plasma cells. Given the aggressive nature and drug resistance of MM cells, identification of novel genes could provide valuable insights for...

Machine learning-based characterization of PANoptosis-related biomarkers and immune infiltration in ulcerative colitis: A comprehensive bioinformatics analysis and experimental validation.

International immunopharmacology
Ulcerative colitis (UC) is a heterogeneous autoimmune condition. PANoptosis, a new form of programmed cell death, plays a role in inflammatory diseases. This study aimed to identify differentially expressed PANoptosis-related genes (PRGs) involved in...

Deep learning imputes DNA methylation states in single cells and enhances the detection of epigenetic alterations in schizophrenia.

Cell genomics
DNA methylation (DNAm) is a key epigenetic mark with essential roles in gene regulation, mammalian development, and human diseases. Single-cell technologies enable profiling DNAm at cytosines in individual cells, but they often suffer from low covera...

Standardizing canine breed data in veterinary records is challenging, but computer vision offers an alternative perspective on breed assignment.

American journal of veterinary research
Dog breed is fundamental health information, especially in the context of breed-linked diseases. The standardization of breed terminology across health records is necessary to leverage the big data revolution for veterinary research. Breed can also i...