OBJECTIVE: Ulcerative colitis (UC), a chronic inflammatory bowel disease, continues to pose substantial challenges in both diagnosis and treatment. The aryl hydrocarbon receptor (AhR) plays a pivotal role in intestinal immune regulation; however, its...
Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC), yet resistance limits its efficacy. The Hedgehog (HH) signaling pathway contributes to drug resistance by maintaining HCC stem cell characteristics, but its role at the ...
During rice cultivation, common rice diseases and pests such as Rice blast, Bacterial blight, Brown-planthopper and Leaf-folder will significantly affect the yield and quality. The current model is limited to detecting rice diseases or pests alone, a...
Estimating time of death based on entomological evidence commonly relies on the "law of total effective temperature", which requires developmental parameters of specific insect taxa. These are often calculated using the method of Ikemoto and Takai. H...
Deep learning models show promise in accelerating the design and optimization of antimicrobial peptides (AMPs), but current methods face challenges, such as low success rates, or large virtual library scales. In this study, we introduce DLFea4AMPGen,...
Brains evolve within specific sensory and physical environments, yet neuroscience has traditionally focused on studying neural circuits in isolation. Understanding of their function requires integrative brain-body testing in realistic contexts. To in...
The Journal of clinical investigation
Oct 15, 2025
Hypoxia in the tumor microenvironment promotes lymphatic metastasis, yet the role of cancer-associated fibroblasts (CAFs) in this process remains insufficiently elucidated in colorectal cancer (CRC). In this study, we developed a large language model...
3D conventional photoacoustic (PA) imaging often suffers from visibility artifacts caused by the limited bandwidth and constrained viewing angles of ultrasound transducers, as well as the use of sparse arrays. PA fluctuation imaging (PAFI), which lev...
Biomedical physics & engineering express
Oct 15, 2025
. Craniotomy is a critical prerequisite for numerous neuro-surgeries, including intracranial tumor resection and cerebral hemorrhage decompression. However, conventional manual craniotomy methods are often time-consuming, labor-intensive, and associa...
Achieving robust and energy-efficient navigation in unknown fluid environments remains a key challenge for bioinspired underwater robots. In this study, we develop a reinforcement learning-based control framework that enables a fish-like swimmer to a...
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