Inspection and diagnosis of construction projects involves health monitoring of buildings and related facilities, and the utilization of renewable energy sources, such as solar energy, is critical to the smooth operation of modern construction projec...
Animal identification is pivotal for ecological studies, yet automated recognition tools for bee species remain underexplored. Here, we present a machine learning approach using a Random Forest algorithm to identify five bee species representing thre...
Spatial proteomics technologies have been pivotal in profiling tumor immune microenvironments at single-cell resolution, advancing our understanding of cancer biology, identifying key cell populations in solid tumors, and predicting treatment respons...
Cancer cells express high levels of programmed cell death-ligand 1 (PD-L1) to evade immune surveillance. PD-L1 interacts with PD-1 on T cells to make them non-functional. Thus, PD-L1 and PD-1 are pivotal targets in cancer immunotherapy. While anti-PD...
Statistical models are powerful tools for describing biological phenomena such as neuronal spiking activity. Although these models have been widely used to study spontaneous and stimulated neuronal activity, they have not yet been applied to analyze ...
The Journal of neuroscience : the official journal of the Society for Neuroscience
Oct 8, 2025
In temporal lobe epilepsy, interictal spikes (IS)-hyper-synchronous bursts of network activity-occur at high rates in between seizures. We sought to understand the influence of IS on working memory by recording hippocampal local field potentials from...
DeepRNA-Reg employs advances in deep learning to enable high-fidelity comparative analysis of paired datasets of high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP). In a HITS-CLIP experimental paradigm where Ag...
Proceedings of the National Academy of Sciences of the United States of America
Oct 7, 2025
Understanding the computational principles of the brain and translating them into neuromorphic hardware and modern deep learning architectures is critical for advancing neuro-inspired AI (NeuroAI). Here, we develop an experimentally constrained, biop...
Proceedings of the National Academy of Sciences of the United States of America
Oct 7, 2025
Protein secretion is an essential process of mammalian cells. In biomanufacturing, this process can be optimized to enhance production yields and biotherapeutic quality. While cell line engineering and bioprocess optimization have yielded high protei...
BACKGROUND: DNA cytosine modifications, including 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC), are key epigenetic regulators with distinct functions. Dissecting the ternary code (C, 5mC, 5hmC) across tissues and cell types remains a cri...
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