Monoclonal antibodies are pivotal in modern therapeutics, yet predicting their subcutaneous bioavailability remains challenging due to the intricacies of the SC environment and the limitations of traditional experimental models. In this study, we int...
Neuroscience and biobehavioral reviews
Aug 5, 2025
Substance use disorders (SUD) are chronic, relapsing conditions marked by high variability in treatment response and frequent relapse. This variability arises from complex interactions among behavioral, environmental, and biological factors unique to...
We present MBPert, a generic computational framework for inferring species interactions and predicting dynamics in time-evolving ecosystems from perturbation and time-series data. In this work, we contextualize the framework in microbial ecosystem mo...
Postmenopausal osteoporosis (PMOP) increases the risk of periodontitis (PD), yet the shared mechanisms remain unclear. Rho-signal transduction genes may play a role due to their involvement in bone remodeling. This study aimed to explore Rho-related ...
To enhance the motion flexibility and environmental adaptability of underwater robots, this study proposes a novel design, Seeker-M, inspired by the locomotion mechanism of the mantis shrimp. The robot imitates the mantis shrimp's multi-pleopod swimm...
Theranostic hydrogels represent a groundbreaking approach by integrating therapeutic and diagnostic capabilities within a single platform, enabling real-time monitoring of wounds and precise treatment applications. These advanced materials are engine...
The degeneration of midbrain dopamine (DA) neurons disrupts the neural control of natural behavior, such as walking, posture, and gait in Parkinson's disease. While some aspects of motor symptoms can be managed by DA replacement therapies, others res...
Journal of controlled release : official journal of the Controlled Release Society
Aug 4, 2025
This paper presents innovative designs for 3D-printed tumbling microrobots, specifically engineered for targeted in vivo drug deliv- ery applications. The microrobot designs, created using stereolithography 3D printing technologies, incorporate perma...
Multiple sclerosis (MS) is a chronic disease of the central nervous system. The occurrence of MS is a phased process while its cause is still unclear. Here, by combining white matter single-nucleus transcriptomic datasets from MS and control samples,...
Multi-cellular organoids are self-assembly aggregates that mimic biological functions and developmental processes of many tissue types in vitro. They are widely employed for disease modeling and functional studies. Hypothalamus-pituitary organoids ca...
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