Resistance to chemotherapy of pancreatic ductal adenocarcinoma (PDAC) is largely driven by intratumoral heterogeneity (ITH) due to tumor cell plasticity and clonal diversity. To develop alternative strategies to overcome this defined mechanism of res...
Many cancer therapies fail in clinical trials despite showing potent efficacy in preclinical studies. One of the key reasons is the adopted preclinical models cannot recapitulate the complex tumor microenvironment (TME) and reflect the heterogeneity ...
In this work, we introduce a benchtop, turn-table photon-counting (PC) micro-computed tomography (CT) scanner and highlight its application for dynamic small animal perfusion imaging.Built on recently published hardware, the system now features a CdT...
Cow's milk protein allergy (CMA) is one of the most common food allergies in children worldwide. However, it is still not well understood why certain children outgrow their CMA and others do not. While there is increasing evidence for a link of CMA w...
Whereas alignment has been fundamental to sequence-based assessments of protein homology, it is ineffective for intrinsically disordered regions (IDRs) due to their lowered sequence conservation and unique sequence properties. Here, we present a web ...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Jul 5, 2025
This paper proposes a novel model updating strategy named SilkwormNet for the first time to address the sex discrimination problem of silkworm pupae with new species. SilkwormNet integrates a ResNet block, a multi-head attention mechanism, and a Sche...
Neuroscience experiments and devices are generating unprecedented volumes of data, but analyzing and validating them presents practical challenges, particularly in annotation. While expert annotation remains the gold standard, it is time consuming to...
Journal of the American Chemical Society
Jul 2, 2025
Fluorescence lifetime imaging microscopy (FLIM) is a powerful optical tool widely used in biomedical research to study changes in a sample's microenvironment. However, data collection and interpretation are often challenging, and traditional methods ...
Emerging spatial profiling technologies have revolutionized our understanding of how tissue architecture shapes disease progression, yet the contribution of cellular diversity remains underexplored. In this issue, Ding and colleagues introduce multio...
Journal of the experimental analysis of behavior
Jul 1, 2025
Traditionally, the experimental analysis of behavior has relied on the single discrete response paradigm (e.g., key pecks, lever presses, screen clicks) to identify behavioral patterns. However, the development and availability of new technology allo...
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