AIMC Topic: Antibodies
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Predicting antibody affinity changes upon mutations by combining multiple predictors.
Scientific reports
Nov 11, 2020
Antibodies are proteins working in our immune system with high affinity and specificity for target antigens, making them excellent tools for both biotherapeutic and bioengineering applications. The prediction of antibody affinity changes upon mutatio...
Machine learning and statistical analyses for extracting and characterizing "fingerprints" of antibody aggregation at container interfaces from flow microscopy images.
Biotechnology and bioengineering
Jul 28, 2020
Therapeutic proteins are exposed to numerous stresses during their manufacture, shipping, storage and administration to patients, causing them to aggregate and form particles through a variety of different mechanisms. These varied mechanisms generate...
ASAP-SML: An antibody sequence analysis pipeline using statistical testing and machine learning.
PLoS computational biology
Apr 27, 2020
Antibodies are capable of potently and specifically binding individual antigens and, in some cases, disrupting their functions. The key challenge in generating antibody-based inhibitors is the lack of fundamental information relating sequences of ant...
Function2Form Bridge-Toward synthetic protein holistic performance prediction.
Proteins
Oct 29, 2019
Protein engineering and synthetic biology stand to benefit immensely from recent advances in silico tools for structural and functional analyses of proteins. In the context of designing novel proteins, current in silico tools inform the user on indiv...
The Immunogenicity of the C Fragment of Tetanus Neurotoxin in Production of Tetanus Antitoxin.
BioMed research international
Dec 31, 2018
The demand of tetanus antitoxin (TAT) as tetanus treatment in developing and underdeveloped countries is still great since it is relatively easy to achieve and affordable. However, there are still issues in the preparation of highly effective TAT wit...
Development of a surface plasmon resonance immunosensor and ELISA for 3-nitrotyrosine in human urine.
Talanta
Dec 1, 2018
3-Nitrotyrosine (3-NT) is thought to be a relevant biomarker of nitrosative stress which is associated with many inflammatory and chronic diseases. It is necessary to develop confidential method for specific and sensitive 3-NT detection. In this pape...
Dynamic changes in specific anti-L-asparaginase antibodies generation during acute lymphoblastic leukemia treatment.
Pharmacological reports : PR
Nov 28, 2018
BACKGROUND: L-asparaginase (L-asp) remains one of the key components of acute lymphoblastic leukemia therapy. Immune reactions to the drug are associated with its diminished activity. The aim of the study was to determine the level of IgM, IgG and Ig...
Development of a sandwich ELISA for determining plasma prolactin concentration in domestic birds.
Domestic animal endocrinology
Nov 24, 2018
The present study was conducted to establish a sandwich ELISA for the determination of prolactin (PRL) concentrations in the plasma of domestic fowls. The assay uses a recombinant goose PRL as the reference standard, expressed in a eukaryotic system,...
Development of a new format of competitive immunochromatographic assay using secondary antibody-europium nanoparticle conjugates for ultrasensitive and quantitative determination of ochratoxin A.
Food chemistry
Sep 19, 2018
In this study, to enhance the sensitivity of conventional immunochromatographic assay (ICA) two strategies including using a high sensitive label and changing the assay format, were simultaneously applied to develop an ultrasensitive format of ICA. I...
Synergistic Use of Gold Nanoparticles (AuNPs) and "Capillary Enzyme-Linked Immunosorbent Assay (ELISA)" for High Sensitivity and Fast Assays.
Sensors (Basel, Switzerland)
Dec 26, 2017
Using gold nanoparticles (AuNPs) on "capillary enzyme-linked immunosorbent assay (ELISA)", we produced highly sensitive and rapid assays, which are the major attributes for point-of-care applications. First, in order to understand the size effect of ...
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