AIMC Topic: Anticoagulants

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The safety and efficacy of full- versus reduced-dose betrixaban in the Acute Medically Ill VTE (Venous Thromboembolism) Prevention With Extended-Duration Betrixaban (APEX) trial.

American heart journal Dec 18, 2016
BACKGROUND: The APEX trial assessed the safety and efficacy of extended-duration thromboprophylaxis using betrixaban versus standard dosing of enoxaparin among hospitalized, acutely ill medical patients. The 80-mg betrixaban dose was halved to 40 mg ...
Pulmonary Embolism Hemorrhage Venous Thromboembolism Enoxaparin Benzamides Factor Xa Inhibitors Humans Female Hospitalization Male Aged Venous Thrombosis Aged, 80 and over Pyridines Anticoagulants Double-Blind Method
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Identifying Drug-Drug Interactions by Data Mining: A Pilot Study of Warfarin-Associated Drug Interactions.

Circulation. Cardiovascular quality and outcomes Nov 8, 2016
BACKGROUND: Knowledge about drug-drug interactions commonly arises from preclinical trials, from adverse drug reports, or based on knowledge of mechanisms of action. Our aim was to investigate whether drug-drug interactions were discoverable without ...
Logistic Models Predictive Value of Tests Anticoagulants Drug Prescriptions Risk Factors Blood Coagulation Humans Administrative Claims, Healthcare Aged Warfarin International Normalized Ratio Machine Learning Polypharmacy Aged, 80 and over Registries Retrospective Studies Male Drug Interactions Female Pilot Projects Data Mining Atrial Fibrillation
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Incidence of severe renal dysfunction among individuals taking warfarin and implications for non-vitamin K oral anticoagulants.

American heart journal Nov 4, 2016
BACKGROUND: The purpose of this study is to assess incidence and risk factors for severe renal dysfunction in patients requiring oral anticoagulation to help guide initial drug choice and provide a rational basis for interval monitoring of renal func...
Coronary Artery Disease Stroke Creatinine Atrial Fibrillation Multivariate Analysis Odds Ratio Kaplan-Meier Estimate Humans Female Logistic Models Risk Factors Aged Renal Insufficiency, Chronic Male Age Factors Middle Aged Anticoagulants Severity of Illness Index Warfarin Incidence
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Risk Assessment for Venous Thromboembolism in Chemotherapy-Treated Ambulatory Cancer Patients.

Medical decision making : an international journal of the Society for Medical Decision Making Aug 19, 2016
OBJECTIVE: To design a precision medicine approach aimed at exploiting significant patterns in data, in order to produce venous thromboembolism (VTE) risk predictors for cancer outpatients that might be of advantage over the currently recommended mod...
Humans Machine Learning Health Status Lipids Anticoagulants Risk Factors Neoplasm Staging Risk Assessment Venous Thromboembolism Neoplasms Outpatients Antineoplastic Agents Body Mass Index
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Development of neuro-fuzzy model to explore gene-nutrient interactions modulating warfarin dose requirement.

Pharmacogenomics Jul 27, 2016
AIM: To investigate the influence of alterations in vitamin K (K1, K2 and K3) in modulating warfarin dose requirement.
Genetic Variation Vitamin K Polymorphism, Genetic Fuzzy Logic Models, Neurological Anticoagulants Warfarin Asian People Humans Adolescent Adult Female Child Male Aged Genotype Middle Aged Young Adult
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Artificial neural network-based pharmacogenomic algorithm for warfarin dose optimization.

Pharmacogenomics Dec 15, 2015
AIM: To develop more precise pharmacogenomic algorithm for prediction of safe and effective dose of warfarin.
Humans Neural Networks, Computer Cytochrome P-450 CYP2C9 Middle Aged Anticoagulants Algorithms Warfarin Female Models, Biological Young Adult Stereoisomerism Adult Male
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Comparison of bleeding risks related to venous thromboembolism prophylaxis in laparoscopic vs open colorectal cancer surgery: a multicenter study in Japanese patients.

American journal of surgery Dec 13, 2015
BACKGROUND: Venous thromboembolism is the most common preventable cause of hospital death. The objective of this study was to clarify risk factors for postoperative bleeding related to thromboprophylaxis after laparoscopic colorectal cancer surgery.
Japan Venous Thromboembolism Fondaparinux Aged Aged, 80 and over Adult Colorectal Neoplasms Male Middle Aged Anticoagulants Laparoscopy Postoperative Hemorrhage Polysaccharides Humans Retrospective Studies Female Risk Factors
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Edoxaban vs warfarin in patients with nonvalvular atrial fibrillation in the US Food and Drug Administration approval population: An analysis from the Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48 (ENGAGE AF-TIMI 48) trial.

American heart journal Dec 1, 2015
BACKGROUND: Edoxaban is a specific anti-Xa inhibitor that, in comparison to warfarin, has been found to be noninferior for the prevention of stroke or systemic embolism (SSE) and to reduce bleeding significantly in patients with nonvalvular atrial fi...
Female Aged Male Humans Blood Coagulation Atrial Fibrillation Drug Approval United States Double-Blind Method United States Food and Drug Administration Dose-Response Relationship, Drug Warfarin Thiazoles Pyridines Factor Xa Stroke Thrombolytic Therapy Factor Xa Inhibitors Anticoagulants Myocardial Infarction
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Risks and Benefits of Pharmacological Prophylaxis for Venous Thromboembolism Prevention in Patients Undergoing Robotic Partial Nephrectomy.

The Journal of urology Nov 26, 2015
PURPOSE: We investigate the safety and efficacy of pharmacological venous thromboembolism prophylaxis in patients treated with robotic partial nephrectomy at our center.
Female Male Middle Aged Risk Assessment Postoperative Complications Humans Retrospective Studies Anticoagulants Venous Thromboembolism Nephrectomy Ohio Incidence Treatment Outcome Follow-Up Studies Operative Time Robotics
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Non-weight-based enoxaparin dosing subtherapeutic in trauma patients.

The Journal of surgical research Oct 21, 2015
BACKGROUND: We report our experience dosing and monitoring enoxaparin with anti-factor Xa activity (anti-FXaA) levels for venous thromboembolism prophylaxis in trauma patients (TP).
Factor Xa Middle Aged Anticoagulants Drug Monitoring Venous Thromboembolism Enoxaparin Female Adult Male Humans Retrospective Studies
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