AIMC Topic: Anticoagulants

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Non-weight-based enoxaparin dosing subtherapeutic in trauma patients.

The Journal of surgical research
BACKGROUND: We report our experience dosing and monitoring enoxaparin with anti-factor Xa activity (anti-FXaA) levels for venous thromboembolism prophylaxis in trauma patients (TP).

Revisiting Warfarin Dosing Using Machine Learning Techniques.

Computational and mathematical methods in medicine
Determining the appropriate dosage of warfarin is an important yet challenging task. Several prediction models have been proposed to estimate a therapeutic dose for patients. The models are either clinical models which contain clinical and demographi...

[Application of an interpretable neural network framework based on the LASSO-proj algorithm for warfarin dose prediction].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Warfarin, a classic oral anticoagulant, is characterized by a narrow therapeutic window and considerable interindividual variability in dosing requirements. This makes precise dose adjustment challenging in clinical practice and increases the risk of...

Anticoagulation colloidal microrobots based on heparin-mimicking polymers.

Journal of colloid and interface science
Coagulation within blood vessels is a major cause of cardiovascular disease and global mortality, highlighting the urgent need for effective anticoagulant strategies. In this study, we introduce a dynamic and highly efficient anticoagulant platform, ...

Applying Machine Learning for Prescriptive Support: A Use Case with Unfractionated Heparin in Intensive Care Units.

Studies in health technology and informatics
Continuous unfractionated heparin is widely used in intensive care, yet its complex pharmacokinetic properties complicate the determination of appropriate doses. To address this challenge, we developed machine learning models to predict over- and und...

Critical Appraisal on the Role of Warfarin in the Current Era.

The Journal of the Association of Physicians of India
Warfarin has been the most extensively used oral anticoagulant (OAC) in medical settings for over 60 years. Its uses, potential adverse effects, and methods for reversing its effects have been firmly established, rendering it a routine medication in ...

Extended Venous Thromboembolism Prophylaxis after Robotic Staging for Endometrial Cancer.

Southern medical journal
OBJECTIVES: Our objectives were to estimate the incidence of venous thromboembolism (VTE) after robotic staging for endometrial cancer and to compare the incidence of VTE in patients who received a single dose of preoperative prophylaxis of enoxapari...

A systemic review and meta-analysis of the effects of perioperative anticoagulant and antiplatelet therapy on bleeding complications in robot-assisted prostatectomy.

European review for medical and pharmacological sciences
OBJECTIVE: Robot-assisted prostatectomy is commonly performed for the management of prostate cancer. The literature has noted that prostate cancer patients are often prone to increased risk for thromboembolic complications. Normally, such situations ...