AIMC Topic: Antineoplastic Combined Chemotherapy Protocols

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A retrospective analysis using deep-learning models for prediction of survival outcome and benefit of adjuvant chemotherapy in stage II/III colorectal cancer.

Journal of cancer research and clinical oncology
PURPOSE: Most of Stage II/III colorectal cancer (CRC) patients can be cured by surgery alone, and only certain CRC patients benefit from adjuvant chemotherapy. Risk stratification based on deep-learning from haematoxylin and eosin (H&E) images has be...

Prediction of Lung Infection during Palliative Chemotherapy of Lung Cancer Based on Artificial Neural Network.

Computational and mathematical methods in medicine
Lung infection seriously affects the effect of chemotherapy in patients with lung cancer and increases pain. The study is aimed at establishing the prediction model of infection in patients with lung cancer during chemotherapy by an artificial neural...

Deep learning for the prediction of early on-treatment response in metastatic colorectal cancer from serial medical imaging.

Nature communications
In current clinical practice, tumor response assessment is usually based on tumor size change on serial computerized tomography (CT) scan images. However, evaluation of tumor response to anti-vascular endothelial growth factor therapies in metastatic...

Deep learning-based predictive biomarker of pathological complete response to neoadjuvant chemotherapy from histological images in breast cancer.

Journal of translational medicine
BACKGROUND: Pathological complete response (pCR) is considered a surrogate endpoint for favorable survival in breast cancer patients treated with neoadjuvant chemotherapy (NAC). Predictive biomarkers of treatment response are crucial for guiding trea...

Survival prediction and treatment optimization of multiple myeloma patients using machine-learning models based on clinical and gene expression data.

Leukemia
Multiple myeloma (MM) remains mostly an incurable disease with a heterogeneous clinical evolution. Despite the availability of several prognostic scores, substantial room for improvement still exists. Promising results have been obtained by integrati...

Artificial Intelligence-Assisted Amphiregulin and Epiregulin IHC Predicts Panitumumab Benefit in Wild-Type Metastatic Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research
PURPOSE: High tumor mRNA levels of the EGFR ligands amphiregulin (AREG) and epiregulin (EREG) are associated with anti-EGFR agent response in metastatic colorectal cancer (mCRC). However, ligand RNA assays have not been adopted into routine practice ...

Identification of drug combinations on the basis of machine learning to maximize anti-aging effects.

PloS one
Aging is a multifactorial process that involves numerous genetic changes, so identifying anti-aging agents is quite challenging. Age-associated genetic factors must be better understood to search appropriately for anti-aging agents. We utilized an ag...

Predicting Tumor Cell Response to Synergistic Drug Combinations Using a Novel Simplified Deep Learning Model.

AMIA ... Annual Symposium proceedings. AMIA Symposium
Drug combinations targeting multiple targets/pathways are believed to be able to reduce drug resistance. Computational models are essential for novel drug combination discovery. In this study, we proposed a new simplified deep learning model, for dr...