AIMC Topic: Antitubercular Agents
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Synthesis, identification and in vitro biological evaluation of some novel quinoline incorporated 1,3-thiazinan-4-one derivatives.
Bioorganic & medicinal chemistry letters
Jun 16, 2016
The present study describes the synthesis of two new series of 3-hydroxy-N-(4-oxo-2-phenyl-1,3-thiazinan-3-yl)-8-(trifluoromethyl)quinoline-2-carboxamide derivatives (4a-j) and 3-((7-chloroquinolin-4-ylamino)methyl)-2-phenyl-1,3-thiazinan-4-one deriv...
Gram-Negative Bacteria
Quinolines
Magnetic Resonance Spectroscopy
Anti-Bacterial Agents
Antitubercular Agents
Spectroscopy, Fourier Transform Infrared
Antimalarials
Microbial Sensitivity Tests
Structure-Activity Relationship
Mycobacterium tuberculosis
Clostridium tetani
Plasmodium falciparum
Thiazines
Effect of goat milk on hepatotoxicity induced by antitubercular drugs in rats.
Journal of food and drug analysis
Jun 2, 2016
Aim of the present study was to assess the hepatoprotective activity of goat milk on antitubercular drug-induced hepatotoxicity in rats. Hepatotoxicity was induced in rats using a combination of isoniazid, rifampicin, and pyrazinamide given orally as...
An Imbalanced Learning based MDR-TB Early Warning System.
Journal of medical systems
May 21, 2016
As a man-made disease, multidrug-resistant tuberculosis (MDR-TB) is mainly caused by improper treatment programs and poor patient supervision, most of which could be prevented. According to the daily treatment and inspection records of tuberculosis (...
Tuberculous Pericarditis is Multibacillary and Bacterial Burden Drives High Mortality.
EBioMedicine
Sep 21, 2015
BACKGROUND: Tuberculous pericarditis is considered to be a paucibacillary process; the large pericardial fluid accumulation is attributed to an inflammatory response to tuberculoproteins. Mortality rates are high. We investigated the role of clinical...
In vitro antimycobacterial activity of six Cameroonian medicinal plants using microplate alamarBlue assay.
International journal of mycobacteriology
Sep 5, 2015
OBJECTIVE/BACKGROUND: The latest incidence of tuberculosis (TB) (per 100,000 people) in Cameroon was 243.00 as of 2011. Over the past 21 years, the value for this indicator has fluctuated between 112.00 in 1990 and 320.00 in 2003. Worldwide, this inc...
Lead Informed Artificial Intelligence Mining of Antitubercular Host Defense Peptides.
Biomacromolecules
May 12, 2025
Identifying host defense peptides (HDPs) that are effective against drug-resistant infections is challenging due to their vast sequence space. Artificial intelligence (AI)-guided design can accelerate HDP discovery, but it traditionally requires larg...
Machine learning-enabled virtual screening indicates the anti-tuberculosis activity of aldoxorubicin and quarfloxin with verification by molecular docking, molecular dynamics simulations, and biological evaluations.
Briefings in bioinformatics
Nov 22, 2024
Drug resistance in Mycobacterium tuberculosis (Mtb) is a significant challenge in the control and treatment of tuberculosis, making efforts to combat the spread of this global health burden more difficult. To accelerate anti-tuberculosis drug discove...
Identification of active molecules against Mycobacterium tuberculosis through machine learning.
Briefings in bioinformatics
Sep 2, 2021
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) and it has been one of the top 10 causes of death globally. Drug-resistant tuberculosis (XDR-TB), extensively resistant to the commonly used first-line drugs, has e...
An explainable machine learning platform for pyrazinamide resistance prediction and genetic feature identification of Mycobacterium tuberculosis.
Journal of the American Medical Informatics Association : JAMIA
Mar 1, 2021
OBJECTIVE: Tuberculosis is the leading cause of death from a single infectious agent. The emergence of antimicrobial resistant Mycobacterium tuberculosis strains makes the problem more severe. Pyrazinamide (PZA) is an important component for short-co...
iATP: A Sequence Based Method for Identifying Anti-tubercular Peptides.
Medicinal chemistry (Shariqah (United Arab Emirates))
Jan 1, 2020
BACKGROUND: Tuberculosis is one of the biggest threats to human health. Recent studies have demonstrated that anti-tubercular peptides are promising candidates for the discovery of new anti-tubercular drugs. Since experimental methods are still labor...
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