AIMC Topic: Antitubercular Agents
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hexanic extract displays synergistic antibacterial activity against .
Natural product research
Dec 25, 2017
A phytochemical and antibacterial study of , a species endemic to Mexico, was performed allowing the isolation of six flavones. The minimal inhibitory concentration (MIC) of the hexanic extract, against H37Rv was 25 μg/mL. The hexanic extract cause...
Rapid and sensitive method for simultaneous determination of first-line anti-tuberculosis drugs in human plasma by HPLC-MS/MS: Application to therapeutic drug monitoring.
Tuberculosis (Edinburgh, Scotland)
Nov 24, 2017
First-line anti-tuberculosis drugs are playing vital roles for curbing rapid spread of tuberculosis. Multidrug therapies are commonly applied in clinical to achieve better treatment outcomes. However, drug resistance and adverse reactions come along ...
Machine learning and docking models for Mycobacterium tuberculosis topoisomerase I.
Tuberculosis (Edinburgh, Scotland)
Jan 20, 2017
There is a shortage of compounds that are directed towards new targets apart from those targeted by the FDA approved drugs used against Mycobacterium tuberculosis. Topoisomerase I (Mttopo I) is an essential mycobacterial enzyme and a promising target...
Drug Design
Dose-Response Relationship, Drug
Structure-Activity Relationship
Bayes Theorem
Humans
Machine Learning
Molecular Docking Simulation
Computer-Aided Design
Protein Conformation
Mycobacterium smegmatis
DNA Topoisomerases, Type I
Topoisomerase I Inhibitors
Antitubercular Agents
Tuberculosis
Mycobacterium tuberculosis
Molecular Targeted Therapy
Artificial Intelligence and Amikacin Exposures Predictive of Outcomes in Multidrug-Resistant Tuberculosis Patients.
Antimicrobial agents and chemotherapy
Sep 23, 2016
Aminoglycosides such as amikacin continue to be part of the backbone of treatment of multidrug-resistant tuberculosis (MDR-TB). We measured amikacin concentrations in 28 MDR-TB patients in Botswana receiving amikacin therapy together with oral levofl...
Artificial Intelligence
Female
Aged
Aged, 80 and over
Humans
Middle Aged
Treatment Outcome
Young Adult
Tuberculosis, Pulmonary
Microbial Sensitivity Tests
Regression Analysis
Adult
Mycobacterium tuberculosis
Antitubercular Agents
Adolescent
Male
Amikacin
Tuberculosis, Multidrug-Resistant
Models, Theoretical
Botswana
Synthesis, identification and in vitro biological evaluation of some novel quinoline incorporated 1,3-thiazinan-4-one derivatives.
Bioorganic & medicinal chemistry letters
Jun 16, 2016
The present study describes the synthesis of two new series of 3-hydroxy-N-(4-oxo-2-phenyl-1,3-thiazinan-3-yl)-8-(trifluoromethyl)quinoline-2-carboxamide derivatives (4a-j) and 3-((7-chloroquinolin-4-ylamino)methyl)-2-phenyl-1,3-thiazinan-4-one deriv...
Mycobacterium tuberculosis
Gram-Negative Bacteria
Quinolines
Magnetic Resonance Spectroscopy
Clostridium tetani
Thiazines
Structure-Activity Relationship
Plasmodium falciparum
Antitubercular Agents
Antimalarials
Anti-Bacterial Agents
Microbial Sensitivity Tests
Spectroscopy, Fourier Transform Infrared
Effect of goat milk on hepatotoxicity induced by antitubercular drugs in rats.
Journal of food and drug analysis
Jun 2, 2016
Aim of the present study was to assess the hepatoprotective activity of goat milk on antitubercular drug-induced hepatotoxicity in rats. Hepatotoxicity was induced in rats using a combination of isoniazid, rifampicin, and pyrazinamide given orally as...
An Imbalanced Learning based MDR-TB Early Warning System.
Journal of medical systems
May 21, 2016
As a man-made disease, multidrug-resistant tuberculosis (MDR-TB) is mainly caused by improper treatment programs and poor patient supervision, most of which could be prevented. According to the daily treatment and inspection records of tuberculosis (...
Tuberculous Pericarditis is Multibacillary and Bacterial Burden Drives High Mortality.
EBioMedicine
Sep 21, 2015
BACKGROUND: Tuberculous pericarditis is considered to be a paucibacillary process; the large pericardial fluid accumulation is attributed to an inflammatory response to tuberculoproteins. Mortality rates are high. We investigated the role of clinical...
In vitro antimycobacterial activity of six Cameroonian medicinal plants using microplate alamarBlue assay.
International journal of mycobacteriology
Sep 5, 2015
OBJECTIVE/BACKGROUND: The latest incidence of tuberculosis (TB) (per 100,000 people) in Cameroon was 243.00 as of 2011. Over the past 21 years, the value for this indicator has fluctuated between 112.00 in 1990 and 320.00 in 2003. Worldwide, this inc...
Lead Informed Artificial Intelligence Mining of Antitubercular Host Defense Peptides.
Biomacromolecules
May 12, 2025
Identifying host defense peptides (HDPs) that are effective against drug-resistant infections is challenging due to their vast sequence space. Artificial intelligence (AI)-guided design can accelerate HDP discovery, but it traditionally requires larg...
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