AIMC Topic: Autophagy

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Structure-based artificial intelligence-aided design of MYC-targeting degradation drugs for cancer therapy.

Biochemical and biophysical research communications Jun 20, 2025
The MYC protein is an oncoprotein that plays a crucial role in various cancers. Although its significance has been well recognized in research, the development of drugs targeting MYC remains relatively slow. In this study, we developed a novel MYC pe...
Humans Artificial Intelligence Neoplasms Apoptosis Autophagy Antineoplastic Agents Proto-Oncogene Proteins c-myc Cell Line, Tumor Proteolysis Cell Proliferation Peptides Drug Design
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Autophagy-related gene SQSTM1 predicts the prognosis of hepatocellular carcinoma.

Computers in biology and medicine Jun 1, 2025
BACKGROUND: The relationship between autophagy and the progression of hepatocellular carcinoma (HCC) is notably substantial, yet the underlying mechanisms remain incompletely elucidated. Our objective is to construct a predictive model, thereby provi...
Liver Neoplasms Carcinoma, Hepatocellular Protein Interaction Maps Prognosis Biomarkers, Tumor Databases, Genetic Autophagy Sequestosome-1 Protein Computational Biology Gene Expression Regulation, Neoplastic Humans
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Autophagy and Apoptosis Specific Knowledgebases-guided Systems Pharmacology Drug Research.

Current cancer drug targets Jan 1, 2019
BACKGROUND: Autophagy and apoptosis are the basic physiological processes in cells that clean up aged and mutant cellular components or even the entire cells. Both autophagy and apoptosis are disrupted in most major diseases such as cancer and neurol...
Drug Development Apoptosis Autophagy Computational Biology Signal Transduction Knowledge Bases Protein Interaction Mapping Humans Molecular Docking Simulation Antineoplastic Agents Neoplasms
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[Effect of Brucea javanica oil emulsion on proliferation, migration and autophagy of non-small cell lung cancer A549 cells and the underlying mechanisms].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences Nov 28, 2018
To investigate the effect of Brucea javanica oil emulsion on proliferation, migration and autophagy of non-small cell lung cancer A549 cells.
 Methods: First, A549 cells were divided into a control group and a low, medium or high dose of Brucea javan...
Plant Oils Cell Proliferation Carcinoma, Non-Small-Cell Lung A549 Cells Humans Autophagy Cell Movement Brucea Lung Neoplasms
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[Y-27632 protects H9c2 cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy pathway].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology Nov 1, 2017
Objective To investigate the protective effect of preconditioning with Rho-kinase inhibitor Y-27632 on H9c2 cardiomyocytes against hypoxia/reoxygenation (H/R) injury, and explore its underlying mechanism. Methods H9c2 cardiomyocytes were divided into...
Myosin Light Chains Beclin-1 L-Lactate Dehydrogenase Cell Hypoxia Autophagy Myocytes, Cardiac Apoptosis Cell Line Cell Survival Rats Animals Signal Transduction Phosphorylation Protective Agents Oxygen Pyridines Amides
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Astragalus Polysaccharide Inhibits Autophagy and Apoptosis from Peroxide-Induced Injury in C2C12 Myoblasts.

Cell biochemistry and biophysics Nov 1, 2015
The aim is to study the effects and underlying mechanisms of astragalus polysaccharide (APS) on the peroxide-induced injury in C2C12 myoblasts in vitro. Cell viability in the presence or absence of APS was detected by the methyl thiazolyl tetrazolium...
Ribosomal Protein S6 Kinases, 70-kDa Microtubule-Associated Proteins Astragalus Plant Cytochromes c Myoblasts Microscopy, Electron Animals Mice Signal Transduction Hydrogen Peroxide Autophagy TOR Serine-Threonine Kinases Polysaccharides Proto-Oncogene Proteins c-bcl-2 bcl-2-Associated X Protein Cell Survival Caspase 3 Blotting, Western Apoptosis Cell Line
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