Microorganisms remain a prolific source of bioactive compounds, yet discovery efforts are often hindered by traditional methods and the repeated isolation of known molecules. In the post-genomics era, advances in genome mining and multi-omics technol...
Emerging evidence suggests that gut microbiota dysbiosis is associated with bone metabolism disorders, including osteopenia (ON) and osteoporosis (OP). However, multi-cohort integrated and association analyses remain underexplored. We conducted a com...
World journal of microbiology & biotechnology
Nov 27, 2025
The growing demand for freshwater, coupled with the increasing volume of industrial and municipal wastewater, has intensified the need for sustainable and eco-friendly reclamation strategies. Recent advancements in microbial biotechnology have emerge...
BACKGROUND: Understanding the functional diversity of the gut microbiome is critical for elucidating its roles in human health and disease. While traditional approaches focus on taxonomic composition, functional configurations of the microbiome remai...
Pathogenic bacteria pose serious threats to public health and environmental safety. Conventional colony counting, a standard method for bacterial detection, is time-consuming and unsuitable for rapid on-site detection. In this work, a flexible ACH/Ag...
Global regulators (GRs) are key transcription factors that orchestrate the expression of multiple genes, playing essential roles in stress responses, virulence, secondary metabolism, and antibiotic resistance-traits that make them powerful tools for ...
Persistent organic pollutants (POPs) are harmful chemicals that resist degradation and remain in the environment for a long time. These pollutants originate from various sources, such as industrial, agricultural, and waste disposal. They contaminate ...
Bacteria utilize cell-cell signaling to coordinate gene expression in populations of cells. Bacterial signal exchange was originally interpreted as a mechanism bacteria use to regulate gene expression in response to changes in cell density, denoted a...
Proceedings of the National Academy of Sciences of the United States of America
Nov 17, 2025
Rubisco is the main gateway through which inorganic carbon enters the biosphere, catalyzing the vast majority of carbon fixation on Earth. This pivotal enzyme has long been observed to be kinetically constrained. Yet, this impression is based on kine...
The escalating global threat of antimicrobial resistance (AMR) necessitates a paradigm shift towards rapid and scalable diagnostic technologies. Conventional antimicrobial susceptibility testing (AST) methods, while reliable, are hindered by prolonge...
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