AIMC Topic: Cytoskeletal Proteins

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Unveiling Berberine analogues as potential inhibitors of Escherichia coli FtsZ through machine learning molecular docking and molecular dynamics approach.

Scientific reports Apr 26, 2025
The bacterial cell division protein FtsZ, a crucial GTPase, plays a vital role in the formation of the contractile Z-ring, which is essential for bacterial cytokinesis. Consequently, inhibiting FtsZ could prevent the formation of proto-filaments and ...
Anti-Bacterial Agents Molecular Docking Simulation Protein Binding Machine Learning Berberine Cytoskeletal Proteins Hydrogen Bonding Escherichia coli Bacterial Proteins Molecular Dynamics Simulation
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In silico method and bioactivity evaluation to discover novel antimicrobial agents targeting FtsZ protein: Machine learning, virtual screening and antibacterial mechanism study.

Naunyn-Schmiedeberg's archives of pharmacology Jul 23, 2024
This research paper utilizes a fused-in-silico approach alongside bioactivity evaluation to identify active FtsZ inhibitors for drug discovery. Initially, ROC-guided machine learning was employed to obtain almost 13182 compounds from three libraries....
Machine Learning Anti-Bacterial Agents Computer Simulation Humans Microbial Sensitivity Tests Staphylococcus aureus Bacillus subtilis Animals Molecular Docking Simulation Drug Discovery Cytoskeletal Proteins Bacterial Proteins Drug Evaluation, Preclinical
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Machine learning interpretable models of cell mechanics from protein images.

Cell Jan 8, 2024
Cellular form and function emerge from complex mechanochemical systems within the cytoplasm. Currently, no systematic strategy exists to infer large-scale physical properties of a cell from its molecular components. This is an obstacle to understandi...
Focal Adhesions Machine Learning Models, Biological Cytoskeletal Proteins Cytoplasm Cell Adhesion
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iMotor-CNN: Identifying molecular functions of cytoskeleton motor proteins using 2D convolutional neural network via Chou's 5-step rule.

Analytical biochemistry Mar 28, 2019
Motor proteins are the driving force behind muscle contraction and are responsible for the active transportation of most proteins and vesicles in the cytoplasm. There are three superfamilies of cytoskeletal motor proteins with various molecular funct...
Molecular Motor Proteins Machine Learning Algorithms Cytoskeletal Proteins Humans Neural Networks, Computer
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Prevalence and genotypes of Giardia lamblia from stray dogs and cats in Guangdong, China.

Veterinary parasitology, regional studies and reports Apr 3, 2018
Giardia lamblia is a worldwide zoonotic intestinal parasite that infects humans and a wide range of mammals including dogs and cats, causing giardiasis with diarrhea. To investigate the infection and distribution of G. lamblia genotypes from stray do...
Cat Diseases China Protozoan Proteins Male Genotype RNA, Ribosomal, 18S Dog Diseases Cytoskeletal Proteins Feces Prevalence Cats Triose-Phosphate Isomerase Sequence Analysis, DNA DNA, Protozoan Female Phylogeny Giardia lamblia Dogs Animals Giardiasis Polymerase Chain Reaction
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Machine Learning Reveals Aneuploidy Characteristics in Cancers: The Impact of BEX4.

Frontiers in bioscience (Landmark edition) Nov 29, 2024
BACKGROUND: Aneuploidy is crucial yet under-explored in cancer pathogenesis. Specifically, the involvement of brain expressed X-linked gene 4 () in microtubule formation has been identified as a potential aneuploidy mechanism. Nevertheless, 's compre...
Myristoylated Alanine-Rich C Kinase Substrate Neoplasms Gene Expression Regulation, Neoplastic Membrane Proteins Cell Proliferation Aneuploidy Cytoskeletal Proteins Humans Machine Learning
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Treatment Potential for Macular Cone Vision in Leber Congenital Amaurosis Due to CEP290 or NPHP5 Mutations: Predictions From Artificial Intelligence.

Investigative ophthalmology & visual science Jun 3, 2019
PURPOSE: To use supervised machine learning to predict visual function from retinal structure in retinitis pigmentosa (RP) and apply these estimates to CEP290- and NPHP5-associated Leber congenital amaurosis (LCA) to determine the potential for funct...
Humans Machine Learning Female Retinitis Pigmentosa Young Adult Tomography, Optical Coherence Adult Mutation Retinal Cone Photoreceptor Cells Visual Fields Calmodulin-Binding Proteins Visual Field Tests Cell Cycle Proteins Male Adolescent Leber Congenital Amaurosis Cytoskeletal Proteins Color Vision Defects Middle Aged Antigens, Neoplasm Genetic Therapy Neoplasm Proteins
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