Fungi are closely associated with various diseases, among which Candida albicans (C. albicans) is recognized as an important pathogen in inflammatory bowel disease (IBD). Fungal pathogenicity is primarily mediated by virulence factors (VFs); therefor...
Phytomedicine : international journal of phytotherapy and phytopharmacology
Sep 15, 2025
INTRODUCTION: The global rise of antimicrobial resistance (AMR), particularly among biofilm-forming bacteria and fungi, has created an urgent need for novel therapeutics. Nordihydroguaiaretic acid (NDGA), a plant-derived polyphenolic lignan, has demo...
International journal of molecular medicine
Aug 24, 2025
Pathogens, including bacteria, viruses and fungi, employ virulence genes to invade their hosts, circumvent immunity and induce diseases. The present review examines the categorization and regulatory mechanisms of virulence genes and their co‑evolutio...
Resistance to antimicrobial agents has become a global threat, estimated to cause 10-million deaths annually by 2050. Antimicrobial peptides are emerging as an alternative and offer advantages over traditional antibiotics. Antimicrobial peptides gene...
ETHNOPHARMACOLOGICAL RELEVANCE: For centuries, propolis has been one of the most important and popular antimicrobial (antibacterial and antifungal) agents used in traditional medicine worldwide, including Central and Eastern Europe. Despite centuries...
ETHNOPHARMACOLOGICAL RELEVANCE: Hydrargyrum chloratum compositum(Hcc) is a traditional Chinese medicine for external use, with the efficacy of 'transforming corrosion and pulling out toxins, removing corrosion and regenerating muscles'. The main comp...
AIMS: C. albicans resistant strains have led to increasingly severe treatment challenges. Antimicrobial peptides with low resistance-inducing propensity for pathogens have been developed. A series of antimicrobial peptides de novo designed through ma...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Feb 8, 2025
Novel antifungal drugs that evade resistance are urgently needed for Candida infections. Antifungal peptides (AFPs) are potential candidates due to their specific mechanism of action, which makes them less prone to developing drug resistance. An AFP ...
Frontiers in cellular and infection microbiology
Jan 6, 2025
BACKGROUND: The rise of antibiotic-resistant pathogens has intensified the search for novel antimicrobial agents. This study aimed to isolate from local soil samples and evaluate its antimicrobial properties, along with optimizing the production of ...
Journal of chemical information and modeling
Jun 20, 2024
Combination therapy is an important direction of continuous exploration in the field of medicine, with the core goals of improving treatment efficacy, reducing adverse reactions, and optimizing clinical outcomes. Machine learning technology holds gre...
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