AIMC Topic: Cell Culture Techniques

Clear Filters Showing 31 to 40 of 57 articles

Intelligent image-based deformation-assisted cell sorting with molecular specificity.

Nature methods May 25, 2020
Although label-free cell sorting is desirable for providing pristine cells for further analysis or use, current approaches lack molecular specificity and speed. Here, we combine real-time fluorescence and deformability cytometry with sorting based on...
Cell Survival Flow Cytometry Sound Microfluidics Cell Proliferation Neutrophils Cell Line Drosophila Cell Size Erythrocyte Deformability Myeloid Cells Erythrocytes HL-60 Cells Cell Culture Techniques Neural Networks, Computer Animals Humans
View on PubMed DOI

Analysis of neurite length of hippocampal neurons cultured into 3D artificial network patterned microfluidic chips.

The International journal of neuroscience Feb 28, 2020
The study aims to lay a foundational probe for the thorough application microfluidic chips in brain function research with microfluidic chips. Neuron slide culture is a common culture method , and the microfluidic chip with the artificial network pa...
Neural Networks, Computer Animals Imaging, Three-Dimensional Hippocampus Neurites Cell Culture Techniques Rats Neurons Microfluidics
View on PubMed DOI

Development of an artificial neural network model to simulate the growth of microalga Chlorella vulgaris incorporating the effect of micronutrients.

Journal of biotechnology Feb 22, 2020
Artificial neural network (ANN) models can be trained to simulate the dynamic behavior of biological systems. In the present study, an ANN model was developed upon multilayer perceptron neural network architecture with 23-20-1 configuration to predic...
Neural Networks, Computer Micronutrients Chlorella vulgaris Nitrogen Microalgae Models, Biological Cell Culture Techniques Algorithms Carbon Dioxide Databases, Factual Temperature
View on PubMed DOI

Robotic fluidic coupling and interrogation of multiple vascularized organ chips.

Nature biomedical engineering Jan 27, 2020
Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we describe an 'interrogator' that employs liquid-handling robotics, custom s...
Lab-On-A-Chip Devices Microfluidics Calibration Cell Culture Techniques Kidney Intestines Liver Skin Heart Robotics Equipment Design Brain Blood-Brain Barrier Lung Humans
View on PubMed DOI

OrgaQuant: Human Intestinal Organoid Localization and Quantification Using Deep Convolutional Neural Networks.

Scientific reports Aug 28, 2019
Organoid cultures are proving to be powerful in vitro models that closely mimic the cellular constituents of their native tissue. Organoids are typically expanded and cultured in a 3D environment using either naturally derived or synthetic extracellu...
Cell Culture Techniques Organoids Humans Image Processing, Computer-Assisted Intestines Neural Networks, Computer Databases, Factual
View on PubMed DOI

A machine-learning approach to calibrate generic Raman models for real-time monitoring of cell culture processes.

Biotechnology and bioengineering Jul 21, 2019
The manufacture of biotherapeutic proteins consists of complex upstream unit operations requiring multiple raw materials, analytical techniques, and control strategies to produce safe and consistent products for patients. Raman spectroscopy is a ubiq...
Humans Models, Biological CHO Cells Cell Culture Techniques Machine Learning Cricetulus Bioreactors Animals Spectrum Analysis, Raman Cell Count
View on PubMed DOI

Automating a Magnetic 3D Spheroid Model Technology for High-Throughput Screening.

SLAS technology Jun 21, 2019
Affordable and physiologically relevant three-dimensional (3D) cell-based assays used in high-throughput screening (HTS) are on the rise in early drug discovery. These technologies have been aided by the recent adaptation of novel microplate treatmen...
Robotics Drug Evaluation, Preclinical High-Throughput Screening Assays Spheroids, Cellular Magnetics Automation, Laboratory Cell Culture Techniques
View on PubMed DOI

Network-Based Drug Discovery: Coupling Network Pharmacology with Phenotypic Screening for Neuronal Excitability.

Journal of molecular biology Jul 18, 2018
Diseases such as chronic pain with complex etiologies are unlikely to respond to single, target-specific therapeutics but rather require intervention at multiple points within a perturbed disease system. Such approaches are being enabled by the rise ...
Computational Biology Humans Neurons Neural Networks, Computer High-Throughput Screening Assays Cell Culture Techniques Drug Discovery ROC Curve
View on PubMed DOI

Environmental properties of cells improve machine learning-based phenotype recognition accuracy.

Scientific reports Jul 4, 2018
To answer major questions of cell biology, it is often essential to understand the complex phenotypic composition of cellular systems precisely. Modern automated microscopes produce vast amounts of images routinely, making manual analysis nearly impo...
Cell Culture Techniques Cellular Microenvironment Image Processing, Computer-Assisted Cluster Analysis Microscopy Software Phenotype Humans Algorithms Single-Cell Analysis Machine Learning
View on PubMed DOI

Deep Learning for Drug Discovery and Cancer Research: Automated Analysis of Vascularization Images.

IEEE/ACM transactions on computational biology and bioinformatics May 29, 2018
Likely drug candidates which are identified in traditional pre-clinical drug screens often fail in patient trials, increasing the societal burden of drug discovery. A major contributing factor to this phenomenon is the failure of traditional in vitro...
Image Processing, Computer-Assisted Drug Discovery Humans Microscopy Antineoplastic Agents Neural Networks, Computer Cell Culture Techniques Neovascularization, Pathologic Deep Learning Neoplasms Extracellular Matrix Pattern Recognition, Automated
View on PubMed DOI
Popular Topics
Recent Journals