AIMC Topic: Cell Culture Techniques
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Development of an artificial neural network model to simulate the growth of microalga Chlorella vulgaris incorporating the effect of micronutrients.
Journal of biotechnology
Feb 22, 2020
Artificial neural network (ANN) models can be trained to simulate the dynamic behavior of biological systems. In the present study, an ANN model was developed upon multilayer perceptron neural network architecture with 23-20-1 configuration to predic...
Robotic fluidic coupling and interrogation of multiple vascularized organ chips.
Nature biomedical engineering
Jan 27, 2020
Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we describe an 'interrogator' that employs liquid-handling robotics, custom s...
OrgaQuant: Human Intestinal Organoid Localization and Quantification Using Deep Convolutional Neural Networks.
Scientific reports
Aug 28, 2019
Organoid cultures are proving to be powerful in vitro models that closely mimic the cellular constituents of their native tissue. Organoids are typically expanded and cultured in a 3D environment using either naturally derived or synthetic extracellu...
A machine-learning approach to calibrate generic Raman models for real-time monitoring of cell culture processes.
Biotechnology and bioengineering
Jul 21, 2019
The manufacture of biotherapeutic proteins consists of complex upstream unit operations requiring multiple raw materials, analytical techniques, and control strategies to produce safe and consistent products for patients. Raman spectroscopy is a ubiq...
Automating a Magnetic 3D Spheroid Model Technology for High-Throughput Screening.
SLAS technology
Jun 21, 2019
Affordable and physiologically relevant three-dimensional (3D) cell-based assays used in high-throughput screening (HTS) are on the rise in early drug discovery. These technologies have been aided by the recent adaptation of novel microplate treatmen...
Network-Based Drug Discovery: Coupling Network Pharmacology with Phenotypic Screening for Neuronal Excitability.
Journal of molecular biology
Jul 18, 2018
Diseases such as chronic pain with complex etiologies are unlikely to respond to single, target-specific therapeutics but rather require intervention at multiple points within a perturbed disease system. Such approaches are being enabled by the rise ...
Environmental properties of cells improve machine learning-based phenotype recognition accuracy.
Scientific reports
Jul 4, 2018
To answer major questions of cell biology, it is often essential to understand the complex phenotypic composition of cellular systems precisely. Modern automated microscopes produce vast amounts of images routinely, making manual analysis nearly impo...
Deep Learning for Drug Discovery and Cancer Research: Automated Analysis of Vascularization Images.
IEEE/ACM transactions on computational biology and bioinformatics
May 29, 2018
Likely drug candidates which are identified in traditional pre-clinical drug screens often fail in patient trials, increasing the societal burden of drug discovery. A major contributing factor to this phenomenon is the failure of traditional in vitro...
Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical- Approach Combining Experiments and Machine Learning.
Frontiers in immunology
Mar 20, 2018
Life-threatening cardiomyopathy is a severe, but common, complication associated with severe trauma or sepsis. Several signaling pathways involved in apoptosis and necroptosis are linked to trauma- or sepsis-associated cardiomyopathy. However, the un...
Carboxybetaine-modified succinylated chitosan-based beads encourage pancreatic β-cells (Min-6) to form islet-like spheroids under in vitro conditions.
Journal of materials science. Materials in medicine
Dec 30, 2017
In vitro, pancreatic β-cells tend to reduce their ability to aggregate into islets and lose insulin-producing ability, likely due to insufficient cell-cell and cell-matrix interactions that are essential for β-cell retention, viability and functional...
Scattering, Radiation
Spheroids, Cellular
Microscopy, Fluorescence
Spectroscopy, Fourier Transform Infrared
Trans-Activators
Carbon
Cell Culture Techniques
Cadherins
Animals
Cell Survival
Betaine
Lasers
Molecular Dynamics Simulation
Insulin
Chitosan
Homeodomain Proteins
Insulin Secretion
Microscopy, Electron, Scanning
Mice
Surface Properties
Insulin-Secreting Cells
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