AIMC Topic: Cell Differentiation
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Whey Protein Complexes with Green Tea Polyphenols: Antimicrobial, Osteoblast-Stimulatory, and Antioxidant Activities.
Cells, tissues, organs
Jan 24, 2019
Polyphenols are known for their antimicrobial activity, whilst both polyphenols and the globular protein β-lactoglobulin (bLG) are suggested to have antioxidant properties and promote cell proliferation. These are potentially useful properties for a ...
DeepNEU: cellular reprogramming comes of age - a machine learning platform with application to rare diseases research.
Orphanet journal of rare diseases
Jan 10, 2019
BACKGROUND: Conversion of human somatic cells into induced pluripotent stem cells (iPSCs) is often an inefficient, time consuming and expensive process. Also, the tendency of iPSCs to revert to their original somatic cell type over time continues to ...
Integrated machine learning pipeline for aberrant biomarker enrichment (i-mAB): characterizing clusters of differentiation within a compendium of systemic lupus erythematosus patients.
AMIA ... Annual Symposium proceedings. AMIA Symposium
Dec 5, 2018
Clusters of differentiation () are cell surface biomarkers that denote key biological differences between cell types and disease state. CD-targeting therapeutic monoclonal antibodies () afford rich trans-disease repositioning opportunities. Within a ...
Acquisition and reconstruction of 4D surfaces of axolotl embryos with the flipping stage robotic microscope.
Bio Systems
Oct 25, 2018
We have designed and constructed a Flipping Stage for a light microscope that can view the whole exterior surface of a 2 mm diameter developing axolotl salamander embryo. It works by rapidly inverting the bottom-heavy embryo, imaging it as it rights ...
Regulation of C2C12 Differentiation and Control of the Beating Dynamics of Contractile Cells for a Muscle-Driven Biosyncretic Crawler by Electrical Stimulation.
Soft robotics
Oct 18, 2018
Biosyncretic robots have potential advantages associated with both living organisms and electromechanical systems. Skeletal muscle tissue is a candidate as bioactuators for biosyncretic robots because of its excellent contraction force and controllab...
Automated Deep Learning-Based System to Identify Endothelial Cells Derived from Induced Pluripotent Stem Cells.
Stem cell reports
May 10, 2018
Deep learning technology is rapidly advancing and is now used to solve complex problems. Here, we used deep learning in convolutional neural networks to establish an automated method to identify endothelial cells derived from induced pluripotent stem...
Role of α-fetoprotein in differentiation of regulatory T lymphocytes.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections
Jan 4, 2018
The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4 lymphocytes with different proliferative status was studied. α-Fetoprotein did not affect the ratio of proliferating and non-prolife...
Simvastatin and nanofibrous poly(l-lactic acid) scaffolds to promote the odontogenic potential of dental pulp cells in an inflammatory environment.
Acta biomaterialia
Dec 30, 2017
UNLABELLED: In this study, we investigated the anti-inflammatory, odontogenic and pro-angiogenic effects of integrating simvastatin and nanofibrous poly(l-lactic acid) (NF-PLLA) scaffolds on dental pulp cells (DPCs). Highly porous NF-PLLA scaffolds t...
Humans
RNA, Messenger
Inflammation
Signal Transduction
Biomarkers
Young Adult
Gene Expression Regulation
Tissue Scaffolds
Simvastatin
Alkaline Phosphatase
Cytoprotection
Lipopolysaccharides
Nanofibers
Mesenchymal Stem Cells
Dental Pulp
Odontogenesis
Cell Differentiation
Neovascularization, Physiologic
Human Umbilical Vein Endothelial Cells
Polyesters
Indoleamine 2,3-Dioxygenase (IDO) Enzyme Links Innate Immunity and Altered T-Cell Differentiation in Non-ST Segment Elevation Acute Coronary Syndrome.
International journal of molecular sciences
Dec 26, 2017
Atherosclerosis is a chronic inflammatory disease characterized by a complex interplay between innate and adaptive immunity. Dendritic cells (DCs) play a key role in T-cell activation and regulation by promoting a tolerogenic environment through the ...
Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification.
Stem cell reports
Oct 12, 2017
Accurately predicting cardioactive effects of new molecular entities for therapeutics remains a daunting challenge. Immense research effort has been focused toward creating new screening platforms that utilize human pluripotent stem cell (hPSC)-deriv...
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