AIMC Topic: Cell Line
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Cheetah: A Computational Toolkit for Cybergenetic Control.
ACS synthetic biology
Apr 27, 2021
Advances in microscopy, microfluidics, and optogenetics enable single-cell monitoring and environmental regulation and offer the means to control cellular phenotypes. The development of such systems is challenging and often results in bespoke setups ...
Magnetically Actuated Drug Delivery Helical Microrobot with Magnetic Nanoparticle Retrieval Ability.
ACS applied materials & interfaces
Apr 20, 2021
Therapeutic drug delivery microrobots capable of accurate targeting using an electromagnetic actuation (EMA) system are being developed. However, these drug delivery microrobots include a large number of magnetic nanoparticles (MNPs) for accurate EMA...
A two-stream convolutional neural network for microRNA transcription start site feature integration and identification.
Scientific reports
Mar 11, 2021
MicroRNAs (miRNAs) play important roles in post-transcriptional gene regulation and phenotype development. Understanding the regulation of miRNA genes is critical to understand gene regulation. One of the challenges to study miRNA gene regulation is ...
Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution.
Biochemical and biophysical research communications
Mar 9, 2021
Free fatty acid receptor 1 (FFAR1 or GPR40) has attracted attention for the treatment of type 2 diabetes mellitus, and various small-molecule agonists have been developed. However, most FFAR1 agonists as well as endogenous ligands, such as linoleic a...
Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning.
PLoS computational biology
Feb 22, 2021
Phenotypic profiling of large three-dimensional microscopy data sets has not been widely adopted due to the challenges posed by cell segmentation and feature selection. The computational demands of automated processing further limit analysis of hard-...
Convolutional Neural Network-Based Artificial Intelligence for Classification of Protein Localization Patterns.
Biomolecules
Feb 11, 2021
Identifying localization of proteins and their specific subpopulations associated with certain cellular compartments is crucial for understanding protein function and interactions with other macromolecules. Fluorescence microscopy is a powerful metho...
Integration of human cell lines gene expression and chemical properties of drugs for Drug Induced Liver Injury prediction.
Biology direct
Jan 9, 2021
MOTIVATION: Drug-induced liver injury (DILI) is one of the primary problems in drug development. Early prediction of DILI can bring a significant reduction in the cost of clinical trials. In this work we examined whether occurrence of DILI can be pre...
Optimal tuning of weighted kNN- and diffusion-based methods for denoising single cell genomics data.
PLoS computational biology
Jan 7, 2021
The analysis of single-cell genomics data presents several statistical challenges, and extensive efforts have been made to produce methods for the analysis of this data that impute missing values, address sampling issues and quantify and correct for ...
Classification of the mechanism of toxicity as applied to human cell line ECV304.
Computer methods in biomechanics and biomedical engineering
Dec 27, 2020
The objective of this study was to identify the pattern of cytotoxicity testing of the human cell line ECV304 using three techniques of an ensemble learning algorithm (bagging, boosting and stacking). The study of cell morphology of ECV304 cell line ...
Repurposing potential of FDA-approved and investigational drugs for COVID-19 targeting SARS-CoV-2 spike and main protease and validation by machine learning algorithm.
Chemical biology & drug design
Dec 22, 2020
The present study aimed to assess the repurposing potential of existing antiviral drug candidates (FDA-approved and investigational) against SARS-CoV-2 target proteins that facilitates viral entry and replication into the host body. To evaluate molec...
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