AIMC Topic: Chemotherapy, Adjuvant

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Computational prediction of multidisciplinary team decision-making for adjuvant breast cancer drug therapies: a machine learning approach.

BMC cancer Dec 1, 2016
BACKGROUND: Multidisciplinary team (MDT) meetings are used to optimise expert decision-making about treatment options, but such expertise is not digitally transferable between centres. To help standardise medical decision-making, we developed a machi...
Humans Machine Learning Algorithms Computer Simulation Clinical Decision-Making Supervised Machine Learning Chemotherapy, Adjuvant Patient Care Team Breast Neoplasms Middle Aged Models, Theoretical Antineoplastic Combined Chemotherapy Protocols Combined Modality Therapy Female Aged Aged, 80 and over Adult
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Cancer Care Access and Outcomes for American Indian Populations in the United States: Challenges and Models for Progress.

Seminars in radiation oncology Nov 24, 2016
Low socioeconomic and health care access realities of being American Indian/Alaskan Native (AI/AN) in the United States combined with decades of data documenting poor cancer outcomes for this population provide a population nested within the United S...
Indians, North American Alaska Natives Radiotherapy Chemotherapy, Adjuvant Humans Neoplasms United States Health Services Accessibility
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SNRFCB: sub-network based random forest classifier for predicting chemotherapy benefit on survival for cancer treatment.

Molecular bioSystems Feb 11, 2016
Adjuvant chemotherapy (CTX) should be individualized to provide potential survival benefit and avoid potential harm to cancer patients. Our goal was to establish a computational approach for making personalized estimates of the survival benefit from ...
Neoplasms Antineoplastic Agents Lung Neoplasms Computational Biology Treatment Outcome Female Reproducibility of Results Breast Neoplasms Male Support Vector Machine Models, Statistical Area Under Curve Kaplan-Meier Estimate Chemotherapy, Adjuvant Humans Neural Networks, Computer Machine Learning Prognosis
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Adjuvant Carboplatin Treatment in 115 Patients With Stage I Seminoma: Retrospective Multicenter Survey.

Clinical genitourinary cancer Dec 17, 2015
BACKGROUND: The administration of carboplatin AUC 7 has become a standard adjuvant option for patients undergoing orchiectomy for stage I seminoma, in alternative to radiotherapy on retroperitoneal lymphnodes or surveillance. The toxicity of AUC 7 ca...
Italy Carboplatin Chemotherapy, Adjuvant Retrospective Studies Young Adult Adult Male Middle Aged Antineoplastic Agents Treatment Outcome Testicular Neoplasms Seminoma Dose-Response Relationship, Drug Humans
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Postoperative photodynamic therapy as a new adjuvant treatment after robot-assisted salvage surgery of recurrent squamous cell carcinoma of the base of tongue.

World journal of surgical oncology Jul 16, 2015
BACKGROUND: For patients who remain with involved resection margins after transoral robot-assisted salvage surgery (TORS) for recurrent squamous cell carcinoma (SCC) at the base of tongue (BOT) following primary (chemo)radiotherapy, further adjuvant ...
Neoplasm Recurrence, Local Tongue Neoplasms Photochemotherapy Salvage Therapy Postoperative Period Chemotherapy, Adjuvant Male Middle Aged Antineoplastic Combined Chemotherapy Protocols Robotics Neoplasm Staging Humans Prognosis Female Carcinoma, Squamous Cell
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Cancer adjuvant chemotherapy strategic classification by artificial neural network with gene expression data: An example for non-small cell lung cancer.

Journal of biomedical informatics May 18, 2015
PURPOSE: Adjuvant chemotherapy (ACT) is used after surgery to prevent recurrence or metastases. However, ACT for non-small cell lung cancer (NSCLC) is still controversial. This study aimed to develop prediction models to distinguish who is suitable f...
Humans Neural Networks, Computer Lung Neoplasms Computational Biology Gene Expression Regulation, Neoplastic Treatment Outcome Carcinoma, Non-Small-Cell Lung Neoplasm Recurrence, Local Neoplasm Metastasis Proportional Hazards Models Kaplan-Meier Estimate Chemotherapy, Adjuvant Reproducibility of Results Aged Male Middle Aged Gene Expression Profiling Machine Learning Algorithms Prognosis Female
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Optimization of guidelines for Risk Of Recurrence/Prosigna testing using a machine learning model: a Swedish multicenter study.

Breast (Edinburgh, Scotland) Aug 1, 2025
PURPOSE: Gene expression profiles are used for decision making in the adjuvant setting in hormone receptor-positive, HER2-negative (HR+/HER2-) breast cancer. While algorithms to optimize testing exist for RS/Oncotype Dx, no such efforts have focused ...
Receptors, Progesterone Machine Learning Prognosis Female Sweden Aged Humans Practice Guidelines as Topic Receptor, ErbB-2 Postmenopause Receptors, Estrogen Chemotherapy, Adjuvant Breast Neoplasms Middle Aged Risk Assessment Gene Expression Profiling Neoplasm Recurrence, Local
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Machine learning prediction of pathological complete response to neoadjuvant chemotherapy with peritumoral breast tumor ultrasound radiomics: compare with intratumoral radiomics and clinicopathologic predictors.

Breast cancer research and treatment Jul 1, 2025
PURPOSE: Noninvasive, accurate and novel approaches to predict patients who will achieve pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) could assist treatment strategies. The aim of this study was to explore the application...
Humans Machine Learning Prognosis Female Aged Antineoplastic Combined Chemotherapy Protocols Treatment Outcome Neoadjuvant Therapy Ultrasonography, Mammary Chemotherapy, Adjuvant Adult Breast Neoplasms Radiomics Middle Aged ROC Curve
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MRI-based multimodal AI model enables prediction of recurrence risk and adjuvant therapy in breast cancer.

Pharmacological research Jun 1, 2025
Timely intervention and improved prognosis for breast cancer patients rely on early metastasis risk detection and accurate treatment predictions. This study introduces an advanced multimodal MRI and AI-driven 3D deep learning model, termed the 3D-MMR...
Middle Aged Risk Assessment Deep Learning Magnetic Resonance Imaging Multimodal Imaging Neoplasm Recurrence, Local Disease-Free Survival Chemotherapy, Adjuvant Female Aged Adult Breast Neoplasms Tumor Microenvironment Humans Prognosis Retrospective Studies
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Monitoring Over Time of Pathological Complete Response to Neoadjuvant Chemotherapy in Breast Cancer Patients Through an Ensemble Vision Transformers-Based Model.

Cancer medicine Dec 1, 2024
BACKGROUND: Morphological and vascular characteristics of breast cancer can change during neoadjuvant chemotherapy (NAC). Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)-acquired pre- and mid-treatment quantitatively capture informatio...
Treatment Outcome Neoadjuvant Therapy Magnetic Resonance Imaging Chemotherapy, Adjuvant Humans Female Aged Adult Breast Neoplasms Middle Aged Deep Learning
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