AIMC Topic: Chromatography, High Pressure Liquid
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Enhancement of multianalyte mass spectrometry detection through response surface optimization by least squares and artificial neural network modelling.
Journal of chromatography. A
Oct 10, 2019
In this work, the use of design of experiments and posterior data modelling by artificial neural network (ANN) and least squares (LS) is presented as a suitable analytical tool for the performance optimization of a tandem mass spectrometric detector ...
Adjusting the dose in paediatric care: dispersing four different aspirin tablets and taking a proportion.
European journal of hospital pharmacy : science and practice
Jun 11, 2019
OBJECTIVES: When caring for children in a hospital setting, tablets are often manipulated at the ward to obtain the right dose. One example is manipulation of tablets containing the slightly water-soluble substance aspirin, used in paediatric care as...
Physicochemical stability of nefopam and nefopam/droperidol solutions in polypropylene syringes for intensive care units.
European journal of hospital pharmacy : science and practice
Jun 11, 2019
INTRODUCTION: Nefopam has been reported to be effective in postoperative pain control with an opioid-sparing effect, but the use of nefopam can lead to nausea and vomiting. To prevent these side effects, droperidol can be mixed with nefopam. In inten...
Identification of the lipid-lowering component of triterpenes from Alismatis rhizoma based on the MRM-based characteristic chemical profiles and support vector machine model.
Analytical and bioanalytical chemistry
May 14, 2019
It has been demonstrated that triterpenes in Alismatis rhizoma (Zexie in Chinese, ZX) contributed to the lipid-lowering effect on high-fat diet-induced hyperlipidemia. Alisol B 23-acetate, one of the abundant triterpenes in ZX, was used as the marker...
Metabolomics Analysis in Acute Paraquat Poisoning Patients Based on UPLC-Q-TOF-MS and Machine Learning Approach.
Chemical research in toxicology
Mar 11, 2019
Most paraquat (PQ) poisoned patients died from acute multiple organ failure (MOF) such as lung, kidney, and heart. However, the exact mechanism of intoxication is still unclear. In order to find out the initial toxic mechanism of PQ poisoning, a bloo...
Investigation of meropenem stability after reconstitution: the influence of buffering and challenges to meet the NHS Yellow Cover Document compliance for continuous infusions in an outpatient setting.
European journal of hospital pharmacy : science and practice
Jan 13, 2019
OBJECTIVES: To determine the influence of different buffers, pH and meropenem concentrations on the degradation rates of meropenem in aqueous solution during storage at 32°C, with the aim of developing a formulation suitable for 24-hour infusion in a...
Quantitation of serum 25(OH)D2 and 25(OH)D3 concentrations by liquid chromatography tandem mass spectrometry in patients with diabetes mellitus.
Journal of food and drug analysis
Dec 31, 2018
Vitamin D has been considered to regulate calcium and phosphorus homeostasis and to preserve skeletal integrity. Serum 25-hydroxyvitamin D (25(OH)D) is the best indicator of vitamin D levels. The association of serum 25(OH)D deficiency with increased...
Simultaneous quantification of six indicator compounds in Wen-Qing-Yin by high-performance liquid chromatography-diode array detection.
Journal of food and drug analysis
Dec 28, 2018
A simple gradient high-performance liquid chromatography with diode array detection (HPLC-DAD) method was used to simultaneously to analyze characteristics of six indicator compounds in the traditional Chinese medicine (TCM) formulation Wen-Qing-Yin ...
Decomposition Kinetics of Omethoate in Blood.
Fa yi xue za zhi
Dec 25, 2018
OBJECTIVES: To study the decomposition kinetics of omethoate in blood.
Determination of Oleandrin in Blood and Liver Samples by LC-MS/MS.
Fa yi xue za zhi
Dec 25, 2018
OBJECTIVES: To develop a liquid chromatography-tandem mass spectrometry （LC-MS/MS） analytical method for the determination of oleandrin in blood and liver tissues, which could be applied to the cases of death caused by oleander poisoning.
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