AIMC Topic: Colitis, Ulcerative

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Combining staged laparoscopic colectomy with robotic completion proctectomy and ileal pouch-anal anastomosis (IPAA) in ulcerative colitis for improved clinical and cosmetic outcomes: a single-center feasibility study and technical description.

Journal of robotic surgery Nov 3, 2022
Robotic proctectomy has been shown to lead to better functional outcomes compared to laparoscopic surgery in rectal cancer. However, in ulcerative colitis (UC), the potential value of robotic proctectomy has not yet been investigated, and in this ind...
Postoperative Complications Treatment Outcome Colitis, Ulcerative Humans Feasibility Studies Anastomosis, Surgical Colectomy Proctocolectomy, Restorative Robotics Laparoscopy Robotic Surgical Procedures
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Deep learning-based automated quantification of goblet cell mucus using histological images as a predictor of clinical relapse of ulcerative colitis with endoscopic remission.

Journal of gastroenterology Oct 3, 2022
BACKGROUND: Mucin depletion is one of the histological indicators of clinical relapse among patients with ulcerative colitis (UC). Mucin depletion is evaluated semiquantitatively by pathologists using histological images. Therefore, the interobserver...
Severity of Illness Index Recurrence Deep Learning Goblet Cells Colitis, Ulcerative Mucins Humans Intestinal Mucosa Mucus Colonoscopy Remission Induction
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UC-NfNet: Deep learning-enabled assessment of ulcerative colitis from colonoscopy images.

Medical image analysis Aug 27, 2022
Ulcerative colitis (UC) belongs to the inflammatory bowel disease (IBD) family, which is mainly caused by inflammation of the tissue in the colon and rectum. The severity of this infection can radically affect the patient's overall well-being. Althou...
Humans Colonoscopy Deep Learning Colitis, Ulcerative Rectum
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Novel deep learning-based computer-aided diagnosis system for predicting inflammatory activity in ulcerative colitis.

Gastrointestinal endoscopy Aug 17, 2022
BACKGROUND AND AIMS: Endoscopy is increasingly performed for evaluating patients with ulcerative colitis (UC). However, its diagnostic accuracy is largely affected by the subjectivity of endoscopists' experience and scoring methods, and scoring of se...
Artificial Intelligence Computers Colonoscopy Severity of Illness Index Humans Intestinal Mucosa Deep Learning Inflammation Colitis, Ulcerative
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Protection against ulcerative colitis and colorectal cancer by evodiamine via anti‑inflammatory effects.

Molecular medicine reports Apr 1, 2022
Evodiamine (Evo) is an alkaloid that can be extracted from the berry fruit and has been reported to exert various pharmacological effects, such as antidiarrheal, antiemetic and antiulcer effects. , the potential effects of Evo were investigated in a...
Quinazolines Dextran Sulfate Animals Colorectal Neoplasms Mice, Inbred C57BL Colitis, Ulcerative Colon Anti-Inflammatory Agents Mice
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Prediction of pouchitis after ileal pouch-anal anastomosis in patients with ulcerative colitis using artificial intelligence and deep learning.

Techniques in coloproctology Mar 1, 2022
BACKGROUND: Pouchitis is one of the major postoperative complications of ulcerative colitis (UC), and it is still difficult to predict the development of pouchitis after ileal pouch-anal anastomosis (IPAA) in UC patients. In this study, we examined w...
Proctocolectomy, Restorative Colonic Pouches Pouchitis Male Middle Aged Postoperative Complications Deep Learning Colitis, Ulcerative Anastomosis, Surgical Retrospective Studies Female Adult Humans Artificial Intelligence
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Combining explainable machine learning, demographic and multi-omic data to inform precision medicine strategies for inflammatory bowel disease.

PloS one Feb 23, 2022
Inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn's disease, affect several million individuals worldwide. These diseases are heterogeneous at the clinical, immunological and genetic levels and result from complex host and en...
Genomics Signal Transduction Colitis, Ulcerative Anti-Inflammatory Agents, Non-Steroidal Crohn Disease Drug Evaluation, Preclinical Tumor Necrosis Factor-alpha Prednisolone Precision Medicine Humans Female Mesalamine Machine Learning Pyrazoles Aged Young Adult Phenylurea Compounds Middle Aged Adult Transcriptome Naphthalenes Male Adolescent
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Artificial intelligence enabled automated diagnosis and grading of ulcerative colitis endoscopy images.

Scientific reports Feb 17, 2022
Endoscopic evaluation to reliably grade disease activity, detect complications including cancer and verification of mucosal healing are paramount in the care of patients with ulcerative colitis (UC); but this evaluation is hampered by substantial int...
Endoscopy, Gastrointestinal Neural Networks, Computer Humans Female Male Image Processing, Computer-Assisted Middle Aged Colitis, Ulcerative Diagnosis, Computer-Assisted
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Relationship between vedolizumab serum concentrations in the induction phase and early and sustained response in the first year of treatment in patients with ulcerative colitis.

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria Dec 22, 2021
OBJECTIVE: Evidence on the usefulness of proactive monitoring of vedolizumab serum concentrations during the induction phase of treatment is limited. The objective of our study was to evaluate the effectiveness of measuring such concentrations during...
Antibodies, Monoclonal, Humanized Colitis, Ulcerative Humans Prospective Studies Adult
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Artificial Neural Network Analysis-Based Immune-Related Signatures of Primary Non-Response to Infliximab in Patients With Ulcerative Colitis.

Frontiers in immunology Dec 21, 2021
Infliximab (IFX) is an effective medication for ulcerative colitis (UC) patients. However, one-third of UC patients show primary non-response (PNR) to IFX. Our study analyzed three Gene Expression Omnibus (GEO) datasets and used the RobustRankAggreg ...
Neural Networks, Computer Colitis, Ulcerative Infliximab Humans Gastrointestinal Agents
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