AIMC Topic: Computational Biology

Clear Filters Showing 2121 to 2130 of 4583 articles

Deep Learning for Automated Feature Discovery and Classification of Sleep Stages.

IEEE/ACM transactions on computational biology and bioinformatics Dec 8, 2020
Convolutional neural networks (CNN) have demonstrated state-of-the-art classification results in image categorization, but have received comparatively little attention for classification of one-dimensional physiological signals. We design a deep CNN ...
Computational Biology Electroencephalography Signal Processing, Computer-Assisted Sleep Stages Humans Deep Learning
View on PubMed DOI

Deep Learning Benchmarks on L1000 Gene Expression Data.

IEEE/ACM transactions on computational biology and bioinformatics Dec 8, 2020
Gene expression data can offer deep, physiological insights beyond the static coding of the genome alone. We believe that realizing this potential requires specialized, high-capacity machine learning methods capable of using underlying biological str...
Models, Genetic Databases, Genetic Cell Line Deep Learning Protein Interaction Maps Computational Biology Humans Algorithms Gene Expression Profiling Transcriptome
View on PubMed DOI

Extracting Inter-Sentence Relations for Associating Biological Context with Events in Biomedical Texts.

IEEE/ACM transactions on computational biology and bioinformatics Dec 8, 2020
We present an analysis of the problem of identifying biological context and associating it with biochemical events described in biomedical texts. This constitutes a non-trivial, inter-sentential relation extraction task. We focus on biological contex...
Databases, Factual Biomedical Research Animals Mice Computational Biology Natural Language Processing Data Mining Humans
View on PubMed DOI

Establishment of a morphological atlas of the Caenorhabditis elegans embryo using deep-learning-based 4D segmentation.

Nature communications Dec 7, 2020
The invariant development and transparent body of the nematode Caenorhabditis elegans enables complete delineation of cell lineages throughout development. Despite extensive studies of cell division, cell migration and cell fate differentiation, cell...
Imaging, Three-Dimensional Computational Biology Cell Movement Cell Differentiation Software Animals Deep Learning Green Fluorescent Proteins Cell Lineage Caenorhabditis elegans Morphogenesis Microscopy, Fluorescence Embryonic Development Animals, Genetically Modified Embryo, Nonmammalian
View on PubMed DOI

Predicting cryptic ligand binding sites based on normal modes guided conformational sampling.

Proteins Dec 5, 2020
To greatly expand the druggable genome, fast and accurate predictions of cryptic sites for small molecules binding in target proteins are in high demand. In this study, we have developed a fast and simple conformational sampling scheme guided by norm...
Molecular Dynamics Simulation Reproducibility of Results Hepacivirus SARS-CoV-2 Coronavirus Papain-Like Proteases Ligands ROC Curve Protein Conformation Regression Analysis Elasticity Karyopherins Humans Computational Biology Receptors, Cytoplasmic and Nuclear Protein Tyrosine Phosphatase, Non-Receptor Type 1 Area Under Curve Antigens, Neoplasm Binding Sites Machine Learning Exportin 1 Protein Antigens, CD Interleukin-2 Coronavirus 3C Proteases Algorithms Models, Statistical
View on PubMed DOI

Tackling the challenges of bioimage analysis.

eLife Dec 2, 2020
Using multiple human annotators and ensembles of trained networks can improve the performance of deep-learning methods in research.
Computational Biology Humans Reproducibility of Results Deep Learning
View on PubMed DOI

How to Determine the Early Warning Threshold Value of Meteorological Factors on Influenza through Big Data Analysis and Machine Learning.

Computational and mathematical methods in medicine Dec 2, 2020
Infectious diseases are a major health challenge for the worldwide population. Since their rapid spread can cause great distress to the real world, in addition to taking appropriate measures to curb the spread of infectious diseases in the event of a...
Incidence Public Health Humans Time Factors Disease Outbreaks Influenza, Human Machine Learning Computational Biology China Meteorological Concepts Algorithms Big Data
View on PubMed DOI

Predicting changes in protein thermodynamic stability upon point mutation with deep 3D convolutional neural networks.

PLoS computational biology Nov 30, 2020
Predicting mutation-induced changes in protein thermodynamic stability (ΔΔG) is of great interest in protein engineering, variant interpretation, and protein biophysics. We introduce ThermoNet, a deep, 3D-convolutional neural network (3D-CNN) designe...
Neural Networks, Computer Imaging, Three-Dimensional Thermodynamics Computational Biology Point Mutation Proteins Protein Stability
View on PubMed DOI

Meningioma Consistency Can Be Defined by Combining the Radiomic Features of Magnetic Resonance Imaging and Ultrasound Elastography. A Pilot Study Using Machine Learning Classifiers.

World neurosurgery Nov 28, 2020
BACKGROUND: The consistency of meningioma is a factor that may influence surgical planning and the extent of resection. The aim of our study is to develop a predictive model of tumor consistency using the radiomic features of preoperative magnetic re...
Meningioma Elasticity Imaging Techniques Meningeal Neoplasms Diffusion Magnetic Resonance Imaging Supratentorial Neoplasms Humans Decision Trees Logistic Models Bayes Theorem Neural Networks, Computer Support Vector Machine Preoperative Care Magnetic Resonance Imaging Machine Learning Intraoperative Care Male Retrospective Studies Middle Aged Female Pilot Projects Aged Computational Biology
View on PubMed DOI

PupStruct: Prediction of Pupylated Lysine Residues Using Structural Properties of Amino Acids.

Genes Nov 28, 2020
Post-translational modification (PTM) is a critical biological reaction which adds to the diversification of the proteome. With numerous known modifications being studied, pupylation has gained focus in the scientific community due to its significant...
Lysine Support Vector Machine Protein Processing, Post-Translational Databases, Protein Computational Biology Proteome
View on PubMed DOI
Popular Topics
Recent Journals