IEEE journal of biomedical and health informatics
May 20, 2019
We consider the problem in precision health of grouping people into subpopulations based on their degree of vulnerability to a risk factor. These subpopulations cannot be discovered with traditional clustering techniques because their quality is eval...
Machine learning is becoming a powerful tool for cancer diagnosis and prognosis based on classification using high dimensional molecular data. However, extracting classification features from high-dimensional datasets remains a challenging problem. P...
Journal of chemical information and modeling
May 13, 2019
An accurate energy scoring function is crucial for protein structure prediction. Given the increasing number of experimentally determined structures, knowledge-based approaches have been widely used to develop scoring functions for protein structure ...
Neuronal synapses transmit electrochemical signals between cells through the coordinated action of presynaptic vesicles, ion channels, scaffolding and adapter proteins, and membrane receptors. In situ structural characterization of numerous synaptic ...
To develop a deep learning system based on 3D convolutional neural networks (CNNs), and to automatically predict EGFR-mutant pulmonary adenocarcinoma in CT images. A dataset of 579 nodules with EGFR mutation status labels of mutant (Mut) or wild-type...
Canonical π-helices are short, relatively unstable secondary structure elements found in proteins. They comprise seven or more residues and are present in 15% of all known protein structures, often in functionally important regions such as ligand- an...
The zinc (Zn) cofactor has been proven to be involved in numerous biological mechanisms and the zinc-binding site is recognized as one of the most important post-translation modifications in proteins. Therefore, accurate knowledge of zinc ions in pro...
Heart disease is a malignant threat to human health. Electrocardiogram (ECG) tests are used to help diagnose heart disease by recording the heart's activity. However, automated medical-aided diagnosis with computers usually requires a large volume of...
BACKGROUND: The diagnosis of multidrug resistant and extensively drug resistant tuberculosis is a global health priority. Whole genome sequencing of clinical Mycobacterium tuberculosis isolates promises to circumvent the long wait times and limited s...
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